HLA Class II (DR) Antibody - Biotin Conjugated (OADB00302)

Catalog No: OADB00302

Size:1 mL

Product Info

• Predicted Species Reactivity: Human
• Product Format: Lyophilized
• Clonality: Monoclonal
• Clone: B-F1
• Isotype: Mouse IgG1
• Host: Mouse
• Conjugation: Biotin
• Application: FC
• Reconstitution and Storage: Reconstitute with 1 mL deionised water Use 10 uL to label 106 cells or 100 uL of whole blood. Stable at +2-8C for six months after reconstitution. DO NOT FREEZE
• Purification: Ion exchange chromatography
• Concentration: 100 tests/1mL
• Preservative: Sodium Azide
• Specificity: Recognises a 28 kDa and 33 kDa protein
• Formulation: Phosphate-buffered saline with 5% BSA and 0.09% sodium azide
• Storage Buffer: Phosphate-buffered saline with 5% BSA and 0.09% sodium azide

Target Info

• Gene Symbol: HLA Class II
• Gene Full Name: major histocompatibility complex, class II, DR alpha
• Alias Symbols: HLA-DRA1
• NCBI Gene Id: 3122; 3125
• Protein Name: HLA class II histocompatibility antigen, DR alpha chain, HLA class II histocompatibility antigen, DR beta 3 chain
• Description of Target: HLA-DRA is one of the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha and a beta chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa and its gene contains 5 exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, and exon 4 encodes the transmembrane domain and the cytoplasmic tail. DRA does not have polymorphisms in the peptide binding part and acts as the sole alpha chain for DRB1, DRB3, DRB4 and DRB5.
• Uniprot ID: P01903, P79483
• Protein Accession #: NP_061984.2
• Nucleotide Accession #: NM_019111.4
• Molecular Weight: 29 kDa