HLA Class II (DQ) Antibody (OADB00298)

Catalog No: OADB00298

Size:200 ug

A typical staining pattern with the B-K27 monoclonal antibody of lymphocytes

Product Info

• Predicted Species Reactivity: Human
• Product Format: Lyophilized
• Clonality: Monoclonal
• Clone: B-K27
• Isotype: Mouse IgG2a
• Host: Mouse
• Application: FC
• Reconstitution and Storage: Stable at +2-8C for 12 months. For longer storage, freeze aliquots
• Purification: Ion exchange chromatography
• Concentration: 1 ug/uL
• Specificity: Recognises a 28 kDa and 33 kDa complex
• Formulation: Phosphate-buffered saline. Sterile-filtered through 0.22 um. Carrier and preservative free
• Storage Buffer: Phosphate-buffered saline. Sterile-filtered through 0.22 um. Carrier and preservative free

Target Info

• Gene Symbol: HLA Class II
• Gene Full Name: major histocompatibility complex, class II, DQ alpha 1
• Alias Symbols: DQA1, DQ-A1, CELIAC1, HLA-DQA
• NCBI Gene Id: 3117; 3118
• Protein Name: HLA class II histocompatibility antigen, DQ alpha 1 chain, HLA class II histocompatibility antigen, DQ alpha 1 chain
• Description of Target: HLA-DQA1 belongs to the HLA class II alpha chain paralogues. The class II molecule is a heterodimer consisting of an alpha (DQA) and a beta chain (DQB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B Lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa. It is encoded by 5 exons; exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, and exon 4 encodes the transmembrane domain and the cytoplasmic tail. Within the DQ molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to four different molecules. Typing for these polymorphisms is routinely done for bone marrow transplantation.
• Uniprot ID: P01909, P01906
• Protein Accession #: NP_002113.2
• Nucleotide Accession #: NM_002122.3
• Molecular Weight: 28 kDa