HIST2H2AA3 Antibody - middle region (ARP51481_T100)

Catalog No: ARP51481_T100

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WB Suggested Anti-HIST2H2AA3 Antibody Titration: 2.5ug/ml
Positive Control: Jurkat cell lysate

Product Info

• Tested Species Reactivity: Human
• Predicted Species Reactivity: Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit
• Product Format: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
• Clonality: Polyclonal
• Host: Rabbit
• Application: WB
• Reconstitution and Storage: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
• Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human HIST2H2AA3
• Purification: Protein A purified
• Predicted Homology Based on Immunogen Sequence: Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%
• Peptide Sequence: Synthetic peptide located within the following region: PRHLQLAIRNDEELNKLLGKVTIAQGGVLPNIQAVLLPKKTESHHKAKGK
• Concentration: 1.0 mg/ml
• Blocking Peptide: Catalog # AAP51481 (Previous Catalog # AAPS28010)
• Reference: Gregory,S.G., (2006) Nature 441 (7091), 315-321

Target Info

• Gene Symbol: HIST2H2AA3
• Gene Full Name: Histone cluster 2, H2aa3
• Alias Symbols: H2A, H2A.2, H2A/O, H2A/q, H2AFO, H2AC19, H2a-615, HIST2H2AA, HIST2H2AA3
• NCBI Gene Id: 8337
• Protein Name: Histone H2A type 3
• Description of Target: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. HIST2H2AA3 is a member of the histone H2A family.Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H2A family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in a histone cluster on chromosome 1. This gene is one of four histone genes in the cluster that are duplicated; this record represents the centromeric copy. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
• Uniprot ID: Q7L7L0
• Protein Accession #: NP_003507
• Nucleotide Accession #: NM_003516
• Protein Size (# AA): 130
• Molecular Weight: 14kDa
• Protein Interactions: USP21; DNAJC2; USP16; AURKB; UBC; WWOX; BAP1; SUZ12; RNF2; HCVgp1; PRMT6; IL33; APP; NOC2L; MEN1; SUMO2; RNF20; MSL2; BMI1; RNF168; HDAC1; PARP1; SRRM1; G3BP1; UBE2H; RCC1; TBL1X;