HERV-FRD Antibody - N-terminal region : HRP (ARP56008_P050-HRP)

Catalog No: ARP56008_P050-HRP

Size:100ul

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Product Info

• Predicted Species Reactivity: Human
• Product Format: Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6.
• Clonality: Polyclonal
• Host: Rabbit
• Conjugation: HRP: Horseradish Peroxidase
• Application: WB
• Reconstitution and Storage: All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil). Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.
• Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human HERV-FRD
• Purification: Affinity Purified
• Predicted Homology Based on Immunogen Sequence: Human: 100%
• Peptide Sequence: Synthetic peptide located within the following region: TGSPYSTNCWLCTSSSTETPGTAYPASPREWTSIEAELHISYRWDPNLKG
• Concentration: 0.5 mg/ml
• Blocking Peptide: For anti-ERVFRD-1 (ARP56008_P050-HRP) antibody is Catalog # AAP56008 (Previous Catalog # AAPP37414)
• Reference: Malassine,A., (er) Retrovirology 5, 6 (2008)

Target Info

• Gene Symbol: ERVFRD-1
• Gene Full Name: Endogenous retrovirus group FRD, member 1
• Alias Symbols: envFRD, UNQ6191, ERVFRDE1, GLLL6191, HERV-FRD, HERV-W/FRD
• NCBI Gene Id: 405754
• Protein Name: HERV-FRD_6p24.1 provirus ancestral Env polyprotein
• Description of Target: Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection. Endogenous envelope proteins may have kept, lost or modified their original function during evolution. This endogenous envelope protein has retained its original fusogenic properties. HERV-FRD can make pseudotypes with MLV, HIV-1 or SIV-1 virions and confer infectivity.Human endogenous retroviruses (HERVs) make up approximately 8% of the human genome. Although most HERVs are nonfunctional, the HERV-W (ERVWE1; MIM 604659) and HERV-FRD envelope (env) proteins can induce cell-cell fusion when expressed in cells possessing appropriate receptors (Blaise et al., 2003 [PubMed 14557543]).[supplied by OMIM].
• Uniprot ID: P60508
• Protein Accession #: NP_997465
• Nucleotide Accession #: NM_207582
• Protein Size (# AA): 538
• Molecular Weight: 60kDa
• Protein Interactions: APP;