HERV-FRD Antibody - N-terminal region (ARP56008_P050)

Catalog No: ARP56008_P050

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Host: Rabbit
Target Name: HERV
Sample Tissue: Human PANC1
Antibody Dilution: 1.0ug/ml

Host: Rabbit
Target Name: ERVFRD-1
Sample Tissue: Human PANC1 Whole Cell
Antibody Dilution: 5ug/ml

Host: Rabbit
Target Name: ERVFRD-1
Sample Tissue: Human A549 Whole Cell
Antibody Dilution: 1ug/ml

Product Info

• Tested Species Reactivity: Human
• Predicted Species Reactivity: Human
• Product Format: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
• Clonality: Polyclonal
• Host: Rabbit
• Application: WB
• Reconstitution and Storage: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
• Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human HERV-FRD
• Purification: Affinity Purified
• Predicted Homology Based on Immunogen Sequence: Human: 100%
• Peptide Sequence: Synthetic peptide located within the following region: TGSPYSTNCWLCTSSSTETPGTAYPASPREWTSIEAELHISYRWDPNLKG
• Concentration: 0.5 mg/ml
• Blocking Peptide: For anti-ERVFRD-1 (ARP56008_P050) antibody is Catalog # AAP56008 (Previous Catalog # AAPP37414)
• Reference: Malassine,A., (er) Retrovirology 5, 6 (2008)
• Publications:

  OVO-like 1 regulates progenitor cell fate in human trophoblast development. Proc Natl Acad Sci U S A. 112, E6175-84 (2015). 26504231

• Description:
  View product citations for HERV-FRD Antibody - N-terminal region (ARP56008_P050) on CiteAb

Target Info

• Gene Symbol: ERVFRD-1
• Gene Full Name: Endogenous retrovirus group FRD, member 1
• Alias Symbols: envFRD, UNQ6191, ERVFRDE1, GLLL6191, HERV-FRD, HERV-W/FRD
• NCBI Gene Id: 405754
• Protein Name: HERV-FRD_6p24.1 provirus ancestral Env polyprotein
• Description of Target: Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection. Endogenous envelope proteins may have kept, lost or modified their original function during evolution. This endogenous envelope protein has retained its original fusogenic properties. HERV-FRD can make pseudotypes with MLV, HIV-1 or SIV-1 virions and confer infectivity.Human endogenous retroviruses (HERVs) make up approximately 8% of the human genome. Although most HERVs are nonfunctional, the HERV-W (ERVWE1; MIM 604659) and HERV-FRD envelope (env) proteins can induce cell-cell fusion when expressed in cells possessing appropriate receptors (Blaise et al., 2003 [PubMed 14557543]).[supplied by OMIM].
• Uniprot ID: P60508
• Protein Accession #: NP_997465
• Nucleotide Accession #: NM_207582
• Protein Size (# AA): 538
• Molecular Weight: 60kDa
• Protein Interactions: APP;