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HDAC3 Antibody (OACA02423)

100 ug
$315.00
In Stock
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Predicted Species Reactivity:
Human
Product Format:
Liquid
Clonality:
Polyclonal
Isotype:
IgG
Host:
Rabbit
Application:
WB, IHC, CHIP
Reconstitution and Storage:
Store at 4C for up to one month. For long term storage, aliquot and store at -20C or -80C. Avoid freeze thaw cycles.
Replacement Item:
This antibody may replace item sc-11417 from Santa Cruz Biotechnology.
Immunogen:
Recombinant human Histone deacetylase 3 protein(1-428aa)
Purification:
Caprylic Acid Ammonium Sulfate Precipitation purified
Predicted Homology Based on Immunogen Sequence:
Human
Datasheets/Manuals:
Printable datasheet for anti-HDAC3 (OACA02423) antibody
Specificity:
Human
Formulation:
Provided in PBS, pH 7.4, 50% Glycerol, 0.03% Proclin 300
Application Data:
WB:1:200-1000, IHC:1:20-1:200
Target Reference:
[1] A hybrid mechanism of action for BCL6 in B cells defined by formation of functionally distinct complexes at enhancers and promoters. Hatzi K., Jiang Y., Huang C., Garrett-Bakelman F., Gearhart M.D., Giannopoulou E.G., Zumbo P., Kirouac K., Bhaskara S., Polo J.M., Kormaksson M., Mackerell A.D. Jr., Xue F., Mason C.E., Hiebert S.W., Prive G.G., Cerchietti L., Bardwell V.J., Elemento O., Melnick A. Cell Rep. 4:578-588 (2013).
[2] Acetylation of a conserved lysine residue in the ATP binding pocket of p38 augments its kinase activity during hypertrophy of cardiomyocytes. Pillai V.B., Sundaresan N.R., Samant S.A., Wolfgeher D., Trivedi C.M., Gupta M.P. Mol. Cell. Biol. 31:2349-2363 (2011).
[3] Initial characterization of the human central proteome. Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17 (2011).
Gene Symbol:
HDAC3
Official Gene Full Name:
histone deacetylase 3
Alias Symbols:
HD3, RPD3, RPD3-2
NCBI Gene Id:
8841
Protein Name:
histone deacetylase 3
Description of Target:
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family. It has histone deacetylase activity and represses transcription when tethered to a promoter. It may participate in the regulation of transcription through its binding with the zinc-finger transcription factor YY1. This protein can also down-regulate p53 function and thus modulate cell growth and apoptosis. This gene is regarded as a potential tumor suppressor gene.
Swissprot Id:
O15379
Protein Accession #:
NP_003874.2
Nucleotide Accession #:
NM_003883.3
Protein Size (# AA):
428
Molecular Weight:
49 kDa
Tissue Tool:
Find tissues and cell lines supported by DNA array analysis to express HDAC3.
RNA Seq:
Find tissues and cell lines supported by RNA-seq analysis to express HDAC3.

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