HDAC2 Recombinant Protein (Human) (OPED00055)

Catalog No: OPED00055

Size:50UG

Product Info

• Predicted Species Reactivity: Homo sapiens|Human
• Product Format: Liquid. In 50mM TRIS, pH 8.0, 138 mM NaCl and 10% glycerol.
• Host: Insect cells
• Additional Information: HDAC2, like the highly homologous HDAC1, is a class I HDAC first identified as a human homolog of the yeast histone deacetylase Rpd3. HDAC2 found, along with HDAC1 in the Sin3, NuRD. In contrast to class II HDACs, which repress cardiac hypertrophy, HDAC2 activity is required for the cardiac hypertrophic response.
• Reconstitution and Storage: Store at -80C
• Purification: Partially purified by single-step affinity chromatography and gel filtration.
• Reference: Hdac2 regulates the cardiac hypertrophic response by modulating Gsk3 beta activity: C.M. Trivedi, et al.; Nat. Med. 13, 324 (2007), Abstract;
  Histone deacetylase 2-mediated deacetylation of the glucocorticoid receptor enables NF-kappa B suppression: K. Ito, et al.; J. Exp. Med. 203, 7 (2006), Abstract;
  Histone deacetylases (HDACs): characterization of the classical HDAC family: A.J. de Ruijter, et al.; Biochem. J. 370, 737 (2003), Abstract;
  CoREST is an integral component of the CoREST- human histone deacetylase complex: A. You, et al.; PNAS U.S.A. 98, 1454 (2001), Abstract;
  Regulation of transcription factor YY1 by acetylation and deacetylation: Y.L. Yao, et al.; Mol. Cell Biol. 21, 5979 (2001), Abstract;
  Analysis of the NuRD subunits reveals a histone deacetylase core complex and a connection with DNA methylation.: Y. Zhang et al.; Genes Dev. 13, 1924 (1999), Abstract;
  Histone deacetylases and SAP18, a novel polypeptide, are components of a human Sin3 complex: Y. Zhang, et al.; Cell 89, 357 (1997), Abstract;
  Histone deacetylases associated with the mSin3 corepressor mediate mad transcriptional repression: C.D. Laherty, et al.; Cell 89, 349 (1997), Abstract;
  Transcriptional repression by YY1 is mediated by interaction with a mammalian homolog of the yeast global regulator RPD3: W.M. Yang, et al.; PNAS U.S.A. 93, 12845 (1996), Abstract;

Target Info

• Gene Symbol: HDAC2
• Gene Full Name: histone deacetylase 2
• Alias Symbols: HD2;histone deacetylase 2;KDAC2;RPD3;transcriptional regulator homolog RPD3;YAF1;YY1-associated factor 1.
• NCBI Gene Id: 3066
• Protein Name: Histone deacetylase 2
• Description of Target: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Forms transcriptional repressor complexes by associating with MAD, SIN3, YY1 and N-COR. Interacts in the late S-phase of DNA-replication with DNMT1 in the other transcriptional repressor complex composed of DNMT1, DMAP1, PCNA, CAF1. Deacetylates TSHZ3 and regulates its transcriptional repressor activity. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development. May be involved in the transcriptional repression of circadian target genes, such as PER1, mediated by CRY1 through histone deacetylation. Involved in MTA1-mediated transcriptional corepression of TFF1 and CDKN1A.
• Uniprot ID: Q92769
• Protein Accession #: NP_001287910.1
• Nucleotide Accession #: NM_001300981.1
• Protein Size (# AA): Recombinant
• Molecular Weight: 66 kDa