HCFC1 Recombinant Protein (OPCD00540)

Catalog No: OPCD00540

HCFC1 Recombinant Protein (OPCD00540) using SDS-PAGE

HCFC1 Recombinant Protein (OPCD00540) using SDS-PAGE

Product Info

• Predicted Species Reactivity: Mouse|Mus musculus
• Product Format: Freeze-dried Powder. PBS, pH7.4, containing 0.01% SKL, 5% Trehalose.
• Host: E.coli
• Conjugation: Unconjugated
• Application: Positive control|Sodium sodecyl sulfate - polyacrylamide gel electrophoresis|Western blot
• Additional Information: Endotoxin Level: < 1.0 EU per 1 ug (determined by the LAL method)
  Residues: Ser107-Thr332
• Reconstitution and Storage: 2°C to 8°C|-80°C
• Concentration: 200 ug/mL (prior to lyoph)
• Purity: > 95%
• Source: E.coli
• Tag: N-terminal His Tag

Target Info

• Gene Symbol: Hcfc1
• Gene Full Name: host cell factor C1
• Alias Symbols: AW060991;C1 factor;HCF;HCF1;host cell factor 1;VP16 accessory protein.
• NCBI Gene Id: 15161
• Protein Name: Host cell factor 1
• Description of Target: Involved in control of the cell cycle (PubMed:9334261, PubMed:9990006). Also antagonizes transactivation by ZBTB17 and GABP2; represses ZBTB17 activation of the p15(INK4b) promoter and inhibits its ability to recruit p300 (By similarity). Coactivator for EGR2 and GABP2 (By similarity). Tethers the chromatin modifying Set1/Ash2 histone H3 'Lys-4' methyltransferase (H3K4me) and Sin3 histone deacetylase (HDAC) complexes (involved in the activation and repression of transcription respectively) together (By similarity). As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues (By similarity). Recruits KMT2E to E2F1 responsive promoters promoting transcriptional activation and thereby facilitates G1 to S phase transition (By similarity).
• Uniprot ID: Q61191
• Protein Accession #: NP_032250.2
• Nucleotide Accession #: NM_008224.4
• Protein Size (# AA): Ser107~Thr332
• Molecular Weight: 29kDa