HCFC1 Recombinant Protein (OPCD00539)

Catalog No: OPCD00539

HCFC1 Recombinant Protein (OPCD00539) using SDS-PAGE

HCFC1 Recombinant Protein (OPCD00539) using SDS-PAGE

Product Info

• Predicted Species Reactivity: Homo sapiens|Human
• Product Format: Freeze-dried Powder. PBS, pH7.4, containing 0.01% SKL, 5% Trehalose.
• Host: E.coli
• Conjugation: Unconjugated
• Application: Positive control|Sodium sodecyl sulfate - polyacrylamide gel electrophoresis|Western blot
• Additional Information: Endotoxin Level: < 1.0 EU per 1 ug (determined by the LAL method)
  Subcellular Location: Cytoplasm, Nucleus, Nucleoplasm, Nucleolus
  Tissue Specificity: Kidney.
  Residues: Asn52-His258
• Reconstitution and Storage: 2°C to 8°C|-80°C
• Concentration: 200 ug/mL (prior to lyoph)
• Purity: > 95%
• Source: E.coli
• Tag: N-terminal His Tag

Target Info

• Gene Symbol: HCFC1
• Gene Full Name: host cell factor C1
• Alias Symbols: C1 factor;CFF;HCF;HCF1;HCF-1;HFC1;host cell factor 1;MRX3;PPP1R89;protein phosphatase 1, regulatory subunit 89;VCAF;VP16 accessory protein;VP16-accessory protein.
• NCBI Gene Id: 3054
• Protein Name: Host cell factor 1
• Description of Target: Involved in control of the cell cycle (PubMed:10629049, PubMed:10779346, PubMed:15190068, PubMed:16624878, PubMed:23629655). Also antagonizes transactivation by ZBTB17 and GABP2; represses ZBTB17 activation of the p15(INK4b) promoter and inhibits its ability to recruit p300 (PubMed:10675337, PubMed:12244100). Coactivator for EGR2 and GABP2 (PubMed:12244100, PubMed:14532282). Tethers the chromatin modifying Set1/Ash2 histone H3 'Lys-4' methyltransferase (H3K4me) and Sin3 histone deacetylase (HDAC) complexes (involved in the activation and repression of transcription, respectively) together (PubMed:12670868). Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1 (PubMed:20200153). As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues (PubMed:20018852). Recruits KMT2E/MLL5 to E2F1 responsive promoters promoting transcriptional activation and thereby facilitates G1 to S phase transition (PubMed:23629655).
• Uniprot ID: P51610
• Protein Accession #: NP_005325.2
• Nucleotide Accession #: NM_005334.2
• Protein Size (# AA): Asn52~His258
• Molecular Weight: 27kDa