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More Information
Predicted Species Reactivity Human
Product Format Liquid. PBS with 0.09% (W/V) sodium azide.
Clonality Polyclonal
Isotype Ig
Host Rabbit
Application WB, FC, IHC-P
Additional Information Function: Involved in oxygen transport from the lung to the various peripheral tissues. Spinorphin: functions as an endogenous inhibitor of enkephalin-degrading enzymes such as DPP3, and as a selective antagonist of the P2RX3 receptor which is involved in pain signaling, these properties implicate it as a regulator of pain and inflammation.
Tissue Location: Red blood cells.
Reconstitution and Storage Maintain refrigerated at 2-8C for up to 2 weeks. For long term storage store at -20C in small aliquots to prevent freeze-thaw cycles.
Replacement Item This antibody may replace item sc-130320 from Santa Cruz Biotechnology.
Immunogen This HBB antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 80-107 amino acids from the C-terminal region of human HBB.
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Predicted Homology Based on Immunogen Sequence Cow, Mouse, Pig, Rabbit, Rat, Chicken
Datasheets/Manuals Printable datasheet for OAAB07804
Intended Use HBB Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Application Info FC: 1:25
WB: 1:2000
FC: 1:10~50
IHC-P: 1:10~50

Brown, N; Alkhayer, K; Clements, R; Singhal, N; Gregory, R; Azzam, S; Li, S; Freeman, E; McDonough, J; Neuronal Hemoglobin Expression and Its Relevance to Multiple Sclerosis Neuropathology. 59, 1-17 (2016). WB, FC, IHC-P, Human 26809286

Gene Symbol HBB
Alias Symbols HBB, Hemoglobin subunit beta, Beta-globin, Hemoglobin beta chain, LVV-hemorphin-7
NCBI Gene Id 3043
Protein Name Hemoglobin subunit beta
Description of Target The alpha (HBA) and beta (HBB) loci determine the structure of the 2 types of polypeptide chains in adult hemoglobin, Hb A. The normal adult hemoglobin tetramer consists of two alpha chains and two beta chains. Mutant beta globin causes sickle cell anemia. Absence of beta chain causes beta-zero-thalassemia. Reduced amounts of detectable beta globin causes beta-plus-thalassemia. The order of the genes in the beta-globin cluster is 5'-epsilon -- gamma-G -- gamma-A -- delta -- beta--3'.
Swissprot Id P68871
Protein Accession # NP_000509.1
Molecular Weight 16 kDa
Tissue Tool Find tissues and cell lines supported by DNA array analysis to express HBB.
RNA Seq Find tissues and cell lines supported by RNA-seq analysis to express HBB.
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