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Catalog No: OACA00500
Size:100ug
Price: $329.00
SKU
OACA00500
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HAVCR2 Antibody - HRP Conjugated (OACA00500)

Datasheets/ManualsPrintable datasheet for HAVCR2 Antibody - HRP Conjugated (OACA00500) (OACA00500)
Product Info
Predicted Species ReactivityHuman
Product FormatLiquid
ClonalityPolyclonal
IsotypeIgG
HostRabbit
ConjugationHRP
ApplicationEnzyme-linked immunosorbent assay
Reconstitution and Storage-20°C or -80°C
ImmunogenRecombinant Human Hepatitis A virus cellular receptor 2 protein (22-202AA)
PurificationProtein G Purified
PurityCaprylic Acid Ammonium Sulfate Precipitation purified
Reference[1] Th1-specific cell surface protein Tim-3 regulates macrophage activation and severity of an autoimmune disease.'Monney L., Sabatos C.A., Gaglia J.L., Ryu A., Waldner H., Chernova T., Manning S., Greenfield E.A., Coyle A.J., Sobel R.A., Freeman G.J., Kuchroo V.K.Nature 415:536-541(2002)
[2] Novel human hepatitis A virus cellular receptor.'Zhang W., Wan T., Li N., Cao X.
[3] A homolog to human kidney injury molecule-1 is expressed in hepatoma cells.'Kuehn E.W., Ichimura T., Bonventre J.V.
Storage BufferPreservative: 0.03% Proclin 300Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Gene SymbolHAVCR2
Gene Full Namehepatitis A virus cellular receptor 2
Alias SymbolsCD366;HAVcr-2;hepatitis A virus cellular receptor 2;kidney injury molecule-3;KIM-3;SPTCL;T cell immunoglobulin mucin 3;T-cell immunoglobulin and mucin domain-containing protein 3;T-cell immunoglobulin mucin family member 3;T-cell immunoglobulin mucin receptor 3;T-cell membrane protein 3;Tim-3;TIM3;TIMD3;TIMD-3.
NCBI Gene Id84868
Protein NameHepatitis A virus cellular receptor 2
Description of TargetCell surface receptor implicated in modulating innate and adaptive immune responses. Generally accepted to have an inhibiting function. Reports on stimulating functions suggest that the activity may be influenced by the cellular context and/or the respective ligand (PubMed:24825777). Regulates macrophage activation (PubMed:11823861). Inhibits T-helper type 1 lymphocyte (Th1)-mediated auto- and alloimmune responses and promotes immunological tolerance (PubMed:14556005). In CD8+ cells attenuates TCR-induced signaling, specifically by blocking NF-kappaB and NFAT promoter activities resulting in the loss of IL-2 secretion. The function may implicate its association with LCK proposed to impair phosphorylation of TCR subunits, and/or LGALS9-dependent recruitment of PTPRC to the immunological synapse (PubMed:24337741, PubMed:26492563). In contrast, shown to activate TCR-induced signaling in T-cells probably implicating ZAP70, LCP2, LCK and FYN (By similarity). Expressed on Treg cells can inhibit Th17 cell responses (PubMed:24838857). Receptor for LGALS9 (PubMed:16286920, PubMed:24337741). Binding to LGALS9 is believed to result in suppression of T-cell responses; the resulting apoptosis of antigen-specific cells may implicate HAVCR2 phosphorylation and disruption of its association with BAG6. Binding to LGALS9 is proposed to be involved in innate immune response to intracellular pathogens. Expressed on Th1 cells interacts with LGALS9 expressed on Mycobacterium tuberculosis-infected macrophages to stimulate antibactericidal activity including IL-1 beta secretion and to restrict intracellular bacterial growth (By similarity). However, the function as receptor for LGALS9 has been challenged (PubMed:23555261). Also reported to enhance CD8+ T-cell responses to an acute infection such as by Listeria monocytogenes (By similarity). Receptor for phosphatidylserine (PtSer); PtSer-binding is calcium-dependent. May recognize PtSer on apoptotic cells leading to their phagocytosis. Mediates the engulfment of apoptotic cells by dendritic cells. Expressed on T-cells, promotes conjugation but not engulfment of apoptotic cells. Expressed on dendritic cells (DCs) positively regulates innate immune response and in synergy with Toll-like receptors promotes secretion of TNF-alpha. In tumor-imfiltrating DCs suppresses nucleic acid-mediated innate immune repsonse by interaction with HMGB1 and interfering with nucleic acid-sensing and trafficking of nucleid acids to endosomes (By similarity). Expressed on natural killer (NK) cells acts as a coreceptor to enhance IFN-gamma production in response to LGALS9 (PubMed:22323453). In contrast, shown to suppress NK cell-mediated cytotoxicity (PubMed:22383801). Negatively regulates NK cell function in LPS-induced endotoxic shock (By similarity).
Uniprot IDQ8TDQ0
  1. What is the species homology for "HAVCR2 Antibody - HRP Conjugated (OACA00500)"?

    The tested species reactivity for this item is "". This antibody is predicted to have homology to "Human".

  2. How long will it take to receive "HAVCR2 Antibody - HRP Conjugated (OACA00500)"?

    This item is available "Domestic: Antibody & Kits: 2 weeks | Proteins: 4-6 weeks | International: Antibody & Kits: 2 weeks | Proteins: 4-6 weeks".

  3. What buffer format is "HAVCR2 Antibody - HRP Conjugated (OACA00500)" provided in?

    This item is provided in "Liquid".
    Additional format options may be available. For more information please contact info@avivasysbio.com.

  4. What are other names for "HAVCR2 Antibody - HRP Conjugated (OACA00500)"?

    This target may also be called "CD366;HAVcr-2;hepatitis A virus cellular receptor 2;kidney injury molecule-3;KIM-3;SPTCL;T cell immunoglobulin mucin 3;T-cell immunoglobulin and mucin domain-containing protein 3;T-cell immunoglobulin mucin family member 3;T-cell immunoglobulin mucin receptor 3;T-cell membrane protein 3;Tim-3;TIM3;TIMD3;TIMD-3." in publications.

  5. What is the shipping cost for "HAVCR2 Antibody - HRP Conjugated (OACA00500)"?

    The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.

  6. What is the guarantee for "HAVCR2 Antibody - HRP Conjugated (OACA00500)"?

    All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.

  7. Can I get bulk pricing for "HAVCR2 Antibody - HRP Conjugated (OACA00500)"?

    You can get bulk pricing for this item by going here.

  8. What is the molecular weight of the protein?

    The molecular weight reported by Uniprot for this item is "".
    Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics.

  9. What protocols are available for "HAVCR2 Antibody - HRP Conjugated (OACA00500)"?

    We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data" tab on the product page.

  10. What are positive controls for "HAVCR2"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  11. What are negative controls for "HAVCR2"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  12. What other proteins interact with "HAVCR2"?

    This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.

  13. What biological processes are associated with "HAVCR2"?

    This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.

  14. What cellular components are associated with "HAVCR2"?

    This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.

  15. What protein functions are associated with "HAVCR2"?

    This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.

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