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HAVCR1 Antibody (OABB00585)

100 ug
$375.00
In Stock
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Gene Symbol:
HAVCR1
NCBI Gene Id:
26762
Official Gene Full Name:
Hepatitis A virus cellular receptor 1
Protein Name:
Hepatitis A virus cellular receptor 1
Swissprot Id:
Q96D42
Protein Accession #:
NP_001166864.1; NP_036338.2
Nucleotide Accession #:
NM_001173393.2; NM_012206.3
Replacement Item:
This antibody may replace item sc-135253 from Santa Cruz Biotechnology.
Description of Target:
KIM1(KIDNEY INJURY MOLECULE 1), also known as HAVCR1, HAVCR or TIM1, is a protein that in humans is encoded by the KIM1 gene. The KIM1 gene is mapped to 5q33.3. Biochemical, mutational, and cell adhesion analyses confirm that Tim1 is capable of homophilic Tim-Tim interactions. The features identified in murine KIM1 is conserved in human KIM1. The KIM1 protein is indeed a receptor for the virus through the infection of canine osteogenic sarcoma cells expressing HAVCR1 with HAV. Using a monoclonal antibody to mouse Tim1, Tim1 is expressed after activation of naive T cells and on T cells differentiated in Th2-polarizing conditions. Ectopic expression of KIM1 during mouse T-cell differentiation leads to production of the Th2-type cytokine Il4, but not the Th1-type cytokine Ifng. KIM1-expressing epithelial cells internalized apoptotic bodies, and Kim1 is directly responsible for phagocytosis in cultured primary rat tubule epithelial cells and in porcine and canine epithelial cell lines.
Host:
Rabbit
Clonality:
Polyclonal
Purification:
Immunogen affinity purified.
Application:
WB, IHC-P, IHC-F
Tissue Tool:
Find tissues and cell lines supported by DNA array analysis to express HAVCR1.
RNA Seq:
Find tissues and cell lines supported by RNA-seq analysis to express HAVCR1.
Immunogen:
A synthetic peptide corresponding to a sequence at the C-terminal of rat KIM1(289-307aa HPRAEDNIYIIEDRSRGAE).
Predicted Homology Based on Immunogen Sequence:
Rat
Product Format:
Lyophilized
Reconstitution and Storage:
Reconstitution: 0.2ml of distilled water will yield a concentration of 500ug/ml.
Storage: At -20C for one year. After reconstitution, at 4C for one month. It can
also be aliquotted and stored frozen at -20C for a longer time. Avoid repeated freezing and thawing
Datasheets/Manuals:
Printable datasheet for anti-HAVCR1 (OABB00585) antibody
Isotype:
IgG
Application Info:
Western blot: 0.1-0.5ug/ml - Rat
Immunohistochemistry (Paraffin-embedded Section): 0.5-1ug/ml - Rat - By Heat
By Heat: Boiling the paraffin sections in 10mM citrate buffer, pH6.0, for 20mins is required for the staining of
formalin/paraffin sections.
Immunohistochemistry (Frozen Section): 0.5-1ug/ml - Rat
Other applications have not been tested.
Optimal dilutions should be determined by end users.
Additional Information:
Content: Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3
Target Reference:
1. de Souza, A. J., Oriss, T. B., O'Malley, K. J., Ray, A., Kane, L. P. T cell Ig and mucin 1 (TIM-1) is expressed on in vivo-activated T cells and provides a costimulatory signal for T cell activation. Proc. Nat. Acad. Sci. 102: 17113-17118, 2005.
2. Feigelstock, D., Thompson, P., Mattoo, P., Zhang, Y., Kaplan, G. G. The human homolog of HAVcr-1 codes for a hepatitis A virus cellular receptor. J. Virol. 72: 6621-6628, 1998.
Publications:

Lobb, I; Davison, M; Carter, D; Liu, W; Haig, A; Gunaratnam, L; Sener, A; Hydrogen Sulfide Treatment Mitigates Renal Allograft Ischemia-Reperfusion Injury during Cold Storage and Improves Early Transplant Kidney Function and Survival Following Allogeneic Renal Transplantation. 194, 1806-15 (2015). WB, IHC-P, IHC-F, Rat 26239336

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