Size:100 ug
$269.00
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OABB00585
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HAVCR1 Antibody (OABB00585)

Catalog#: OABB00585
Domestic: within 1 week delivery | International: 1 week
This product is Genway GWB-BBP507
More Information
Predicted Species Reactivity Rat
Product Format LyophilizedEach vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg NaN3
Clonality Polyclonal
Isotype IgG
Host Rabbit
Application WB, IHC-P, IHC-F
Additional Information Tissue Specificity: Expressed at a low level in normal kidney but are increased dramatically in postischemic kidney. Expressed in proliferating bromodeoxyuridine-positive and dedifferentiated vimentin-positive epithelial cells in regenerating proximal tubules.
Subcellular Location: Membrane ; Single-pass type I membrane protein.
Reconstitution and Storage 0.2ml of distilled water will yield a concentration of 500 ug/ml. At -20C for one year. After reconstitution, at 4C for one month. It can also be aliquotted and stored frozen at -20C for a longer time. Avoid repeated freezing and thawing
Replacement Item This antibody may replace item sc-135253 from Santa Cruz Biotechnology.
Immunogen A synthetic peptide corresponding to a sequence at the C-terminal of rat KIM1(289-307aa HPRAEDNIYIIEDRSRGAE).
Purification Immunogen affinity purified.
Datasheets/Manuals Printable datasheet for anti-HAVCR1 (OABB00585) antibody
Specificity No cross reactivity with other proteins.
Application Info WB: 0.1-0.5 ug/mL. Tested Species: Rat
IHC-P: 0.5-1 ug/mL. Tested: Rat. Antigen retrieval is by heat, where boiling the paraffin sections in 10mM citrate buffer (pH 6.0) for 20 mins is required for the staining of formalin/paraffin sections.
IHC-F: 0.5-1 ug/mL. Tested: Rat.
Target Reference 1. de Souza, A. J., Oriss, T. B., O'Malley, K. J., Ray, A., Kane, L. P. T cell Ig and mucin 1 (TIM-1) is expressed on in vivo-activated T cells and provides a costimulatory signal for T cell activation. Proc. Nat. Acad. Sci. 102: 17113-17118, 2005.
2. Feigelstock, D., Thompson, P., Mattoo, P., Zhang, Y., Kaplan, G. G. The human homolog of HAVcr-1 codes for a hepatitis A virus cellular receptor. J. Virol. 72: 6621-6628, 1998.
Publications

Lobb, I; Davison, M; Carter, D; Liu, W; Haig, A; Gunaratnam, L; Sener, A; Hydrogen Sulfide Treatment Mitigates Renal Allograft Ischemia-Reperfusion Injury during Cold Storage and Improves Early Transplant Kidney Function and Survival Following Allogeneic Renal Transplantation. 194, 1806-15 (2015). WB, IHC-P, IHC-F, Rat26239336

Gene Symbol HAVCR1
Official Gene Full Name Hepatitis A virus cellular receptor 1
NCBI Gene Id 26762
Protein Name Hepatitis A virus cellular receptor 1
Description of Target KIM1(KIDNEY INJURY MOLECULE 1), also known as HAVCR1, HAVCR or TIM1, is a protein that in humans is encoded by the KIM1 gene. The KIM1 gene is mapped to 5q33.3. Biochemical, mutational, and cell adhesion analyses confirm that Tim1 is capable of homophilic Tim-Tim interactions. The features identified in murine KIM1 is conserved in human KIM1. The KIM1 protein is indeed a receptor for the virus through the infection of canine osteogenic sarcoma cells expressing HAVCR1 with HAV. Using a monoclonal antibody to mouse Tim1, Tim1 is expressed after activation of naive T cells and on T cells differentiated in Th2-polarizing conditions. Ectopic expression of KIM1 during mouse T-cell differentiation leads to production of the Th2-type cytokine Il4, but not the Th1-type cytokine Ifng. KIM1-expressing epithelial cells internalized apoptotic bodies, and Kim1 is directly responsible for phagocytosis in cultured primary rat tubule epithelial cells and in porcine and canine epithelial cell lines.
Swissprot Id Q96D42
Protein Accession # NP_001166864.1; NP_036338.2
Nucleotide Accession # NM_001173393.2; NM_012206.3
Molecular Weight 34 kDa
Tissue Tool Find tissues and cell lines supported by DNA array analysis to express HAVCR1.
RNA Seq Find tissues and cell lines supported by RNA-seq analysis to express HAVCR1.
  1. What is the species homology for "HAVCR1 Antibody (OABB00585)"?

    The tested species reactivity for this item is "". This antibody is predicted to have homology to "Rat".

  2. How long will it take to receive "HAVCR1 Antibody (OABB00585)"?

    This item is available "Domestic: within 1 week delivery | International: 1 week".

  3. What buffer format is "HAVCR1 Antibody (OABB00585)" provided in?

    This item is provided in "LyophilizedEach vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg NaN3".
    Additional format options may be available. For more information please contact info@avivasysbio.com.

  4. What are other names for "HAVCR1 Antibody (OABB00585)"?

    This target may also be called "" in publications.

  5. What is the shipping cost for "HAVCR1 Antibody (OABB00585)"?

    The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.

  6. What is the guarantee for "HAVCR1 Antibody (OABB00585)"?

    All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.

  7. Can I get bulk pricing for "HAVCR1 Antibody (OABB00585)"?

    You can get bulk pricing for this item by going here.

  8. What is the molecular weight of the protein?

    The molecular weight reported by Uniprot for this item is "34 kDa".
    Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics.

  9. What protocols are available for "HAVCR1 Antibody (OABB00585)"?

    We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data tab on the product page.

  10. What are positive controls for "HAVCR1"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  11. What are negative controls for "HAVCR1"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  12. What other proteins interact with "HAVCR1"?

    This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.

  13. What biological processes are associated with "HAVCR1"?

    This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.

  14. What cellular components are associated with "HAVCR1"?

    This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.

  15. What protein functions are associated with "HAVCR1"?

    This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.

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