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Catalog No: OAAB16678
Size:400ul
Price: $438.00
SKU
OAAB16678
Availability: Domestic: within 1-2 week delivery | International: within 1-2 week delivery
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  • $55: Antibody & Protein in US
  • $55 + $25/Kit in US
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Datasheets/ManualsPrintable datasheet for OAAB16678
Product Info
Predicted Species ReactivityHuman
Product FormatPurified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
ClonalityPolyclonal
IsotypeIg
HostRabbit
ApplicationWB, IHC, IF
Additional InformationPrecautions: Hamartin (TSC1) Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
::Function: In complex with TSC2, inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling. Seems not to be required for TSC2 GAP activity towards RHEB. Implicated as a tumor suppressor. Involved in microtubule-mediated protein transport, but this seems to be due to unregulated mTOR signaling
::Cellular Location: Cytoplasm. Membrane; Peripheral membrane protein. Note=At steady state found in association with membranes
Tissue Location: Highly expressed in skeletal muscle, followed by heart, brain, placenta, pancreas, lung, liver and kidney. Also expressed in embryonic kidney cells
Reconstitution and StorageMaintain refrigerated at 2-8C for up to 2 weeks. For long term storage store at -20C in small aliquots to prevent freeze-thaw cycles.
ImmunogenThis Hamartin (TSC1) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 401-430 amino acids from the Central region of human Hamartin (TSC1).
Predicted Homology Based on Immunogen SequenceHuman
ConcentrationApproximately 0.5mg/ml. Actual concentration varies with each lot.
Application InfoWB: 1:1000
IHC-P: 1:10~50
IF: 1:10~50
Gene SymbolTSC1
Alias SymbolsLAM, TSC
NCBI Gene Id7248
Protein NameHamartin
Description of TargetPeptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Uniprot IDQ92574
Protein Accession #NP_000359.1
Molecular Weight129767 Da
  1. What is the species homology for "TSC1 Antibody - middle region (OAAB16678)"?

    The tested species reactivity for this item is "". This antibody is predicted to have homology to "Human".

  2. How long will it take to receive "TSC1 Antibody - middle region (OAAB16678)"?

    This item is available "Domestic: within 1-2 week delivery | International: within 1-2 week delivery".

  3. What buffer format is "TSC1 Antibody - middle region (OAAB16678)" provided in?

    This item is provided in "Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.".
    Additional format options may be available. For more information please contact info@avivasysbio.com.

  4. What are other names for "TSC1 Antibody - middle region (OAAB16678)"?

    This target may also be called "LAM, TSC" in publications.

  5. What is the shipping cost for "TSC1 Antibody - middle region (OAAB16678)"?

    The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.

  6. What is the guarantee for "TSC1 Antibody - middle region (OAAB16678)"?

    All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.

  7. Can I get bulk pricing for "TSC1 Antibody - middle region (OAAB16678)"?

    You can get bulk pricing for this item by going here.

  8. What is the molecular weight of the protein?

    The molecular weight reported by Uniprot for this item is "129767 Da".
    Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics.

  9. What protocols are available for "TSC1 Antibody - middle region (OAAB16678)"?

    We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data" tab on the product page.

  10. What are positive controls for "TSC1"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  11. What are negative controls for "TSC1"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  12. What other proteins interact with "TSC1"?

    This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.

  13. What biological processes are associated with "TSC1"?

    This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.

  14. What cellular components are associated with "TSC1"?

    This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.

  15. What protein functions are associated with "TSC1"?

    This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.

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