Catalog No: OOMC00035
Price: $0.00
SKU
OOMC00035
Availability: Domestic: within 1-2 weeks delivery | International: 1-2 weeks
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Datasheets/Manuals | Printable datasheet for OOMC00035 |
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Product Format | Lyophilized |
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Additional Information | Molecular Formula: C20H20BrN3O2S - 2HCl |
:: | Chemical Name: N-[2-[[3-(4-Bromophenyl)-2-propen-1-yl]amino]ethyl]-5-isoquinolinesulfonamide dihydrochloride |
Reconstitution and Storage | Soluble in DMSO (up to 50 mg/ml) or in Water (up to 10 mg/ml). Store desiccated as supplied at -20°C for up to 1 year. Store solutions at -20°C for up to 3 months. |
Purity | > 98% (TLC); NMR (Conforms) |
Reference | 1) Lochner and Moolman (2006), The many faces of H89: a review; Cardiovasc. Drugs, 24 261 2) Bain et al. (2007), The selectivity of protein kinase inhibitors: a further update; Biochem.J. 408(Pt3) 297 |
Description of Target | Protein kinase A inhibitor, IC50=135 nM. Also inhibits several other kinases, IC50=80, 120, 270, 2600 and 2800 nM for S6K1, MSK1, ROCKII, PKB-alpha and MAPKAP-K1b, respectively. A useful probe for PKA but due to selectivity issues, H-89 should be used along with other PKA inhibitors to ascertain the role of PKA in cellular signaling pathways. Has been used in a novel assay employing in vivo substrate screening. Cell permeable. |
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Molecular Weight | 519.28 g/mol |
- Protocol:
- Reconstitution & Storage Instructions
- Western Blotting/Immunoblotting (WB/IB) Protocol
- Immunohistochemistry (IHC) Protocol
- Immunocytochemistry (ICC) Protocol
- Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
- Blocking Peptide Competition Protocol (BPCP)
- Immunoprecipitation (IP) Protocol
- Antibody Array (AA) Protocol
- Tips Information:
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