Catalog No: OOMC00035
Price: $0.00
SKU
OOMC00035
Availability: Domestic: within 1-2 weeks delivery | International: 1-2 weeks
Bulk
Order
Aviva's
Satisfaction
Guarantee
Contact Us:
Shipping Info:
  • $55: Antibody & Protein in US
  • $55 + $25/Kit in US
  • Contact us for international orders.

H89 - 2HCl (OOMC00035)

Datasheets/ManualsPrintable datasheet for OOMC00035
Product Info
Product FormatLyophilized
Additional InformationMolecular Formula: C20H20BrN3O2S - 2HCl
::Chemical Name: N-[2-[[3-(4-Bromophenyl)-2-propen-1-yl]amino]ethyl]-5-isoquinolinesulfonamide dihydrochloride
Reconstitution and StorageSoluble in DMSO (up to 50 mg/ml) or in Water (up to 10 mg/ml). Store desiccated as supplied at -20°C for up to 1 year. Store solutions at -20°C for up to 3 months.
Purity> 98% (TLC); NMR (Conforms)
Reference1) Lochner and Moolman (2006), The many faces of H89: a review; Cardiovasc. Drugs, 24 261 2) Bain et al. (2007), The selectivity of protein kinase inhibitors: a further update; Biochem.J. 408(Pt3) 297
Description of TargetProtein kinase A inhibitor, IC50=135 nM. Also inhibits several other kinases, IC50=80, 120, 270, 2600 and 2800 nM for S6K1, MSK1, ROCKII, PKB-alpha and MAPKAP-K1b, respectively. A useful probe for PKA but due to selectivity issues, H-89 should be used along with other PKA inhibitors to ascertain the role of PKA in cellular signaling pathways. Has been used in a novel assay employing in vivo substrate screening. Cell permeable.
Molecular Weight519.28 g/mol
Write Your Own Review
You're reviewing:H89 - 2HCl (OOMC00035)
Your Rating