Catalog No: OPCD03781
Price: $0.00
SKU
OPCD03781
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Datasheets/Manuals | Printable datasheet for H2AFY Recombinant Protein (OPCD03781) |
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Predicted Species Reactivity | Homo sapiens|Human |
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Product Format | Freeze-dried Powder. PBS, pH7.4, containing 0.01% SKL, 5% Trehalose. |
Host | E.coli |
Conjugation | Unconjugated |
Application | Positive control|Sodium sodecyl sulfate - polyacrylamide gel electrophoresis|Western blot |
Additional Information | Endotoxin Level: < 1.0 EU per 1 ug (determined by the LAL method) |
:: | Residues: Ile109-Asn369 |
Reconstitution and Storage | 2°C to 8°C|-80°C |
Concentration | 200 ug/mL (prior to lyoph) |
Purity | > 95% |
Source | E.coli |
Tag | N-terminal His and GST Tag |
Gene Symbol | MACROH2A1 |
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Gene Full Name | macroH2A.1 histone |
Alias Symbols | core histone macro-H2A.1;H2A histone family member Y;H2A.y;H2A/y;H2AF12M;H2AFY;histone H2A.y;histone macroH2A1;histone macroH2A1.1;histone macroH2A1.2;MACROH2A1.1;macroH2A1.2;medulloblastoma antigen MU-MB-50.205;mH2A1. |
NCBI Gene Id | 9555 |
Protein Name | Core histone macro-H2A.1 |
Description of Target | Variant histone H2A which replaces conventional H2A in a subset of nucleosomes where it represses transcription (PubMed:12718888, PubMed:15621527, PubMed:16428466). Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Involved in stable X chromosome inactivation (PubMed:15897469). Inhibits the binding of transcription factors, including NF-kappa-B, and interferes with the activity of remodeling SWI/SNF complexes (PubMed:12718888, PubMed:16428466). Inhibits histone acetylation by EP300 and recruits class I HDACs, which induces a hypoacetylated state of chromatin (PubMed:16428466, PubMed:16107708). |
Uniprot ID | O75367 |
Protein Accession # | NP_001035248.1 |
Nucleotide Accession # | NM_001040158.1 |
Protein Size (# AA) | Ile109~Asn369 |
Molecular Weight | 60kDa |
- Protocol:
- Reconstitution & Storage Instructions
- Western Blotting/Immunoblotting (WB/IB) Protocol
- Immunohistochemistry (IHC) Protocol
- Immunocytochemistry (ICC) Protocol
- Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
- Blocking Peptide Competition Protocol (BPCP)
- Immunoprecipitation (IP) Protocol
- Antibody Array (AA) Protocol
- Tips Information:
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