H2AFX Recombinant Protein (OPCD03780)

Catalog No: OPCD03780

Product Info

• Predicted Species Reactivity: Homo sapiens|Human
• Product Format: Freeze-dried Powder. PBS, pH7.4, containing 0.01% SKL, 5% Trehalose.
• Host: E.coli
• Conjugation: Unconjugated
• Application: Positive control|Sodium sodecyl sulfate - polyacrylamide gel electrophoresis|Western blot
• Additional Information: Endotoxin Level: < 1.0 EU per 1 ug (determined by the LAL method)
  Residues: Ser2-Tyr143
  Subcellular Location: Nucleus. Chromosome
• Reconstitution and Storage: 2°C to 8°C|-80°C
• Concentration: 200 ug/mL (prior to lyoph)
• Purity: > 95%
• Source: E.coli
• Tag: N-terminal His and GST Tag

Target Info

• Gene Symbol: H2AX
• Gene Full Name: H2A.X variant histone
• Alias Symbols: H2A histone family member X;H2A.X;H2A/X;H2AFX;H2AX histone;histone H2A.x;histone H2AX.
• NCBI Gene Id: 3014
• Protein Name: Histone H2AX
• Description of Target: Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Required for checkpoint-mediated arrest of cell cycle progression in response to low doses of ionizing radiation and for efficient repair of DNA double strand breaks (DSBs) specifically when modified by C-terminal phosphorylation.
• Uniprot ID: P16104
• Protein Accession #: NP_002096.1
• Nucleotide Accession #: NM_002105.2
• Protein Size (# AA): Ser2~Tyr143
• Molecular Weight: 45kDa