H2AFX Antibody (Phospho-Tyr142) (OASG03376)

Catalog No: OASG03376

Size:100 uL

Western Blot

Product Info

• Predicted Species Reactivity: Human, Mouse, Rat
• Product Format: Liquid PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
• Clonality: Polyclonal
• Isotype: IgG
• Host: Rabbit
• Application: WB
  Cellular Localization: Nucleus Chromosome
• Reconstitution and Storage: Store at -20C. Avoid repeated freeze/thaw cycles.
• Immunogen: Synthetic Peptide
• Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using specific immunogen.
• Concentration: 1 mg/ml
• Target Post-Translational Modification: Phospho-Tyr142
• Specificity: The antibody detects endogenous Histone H2A.X (Phospho Tyr142) protein.
• Application Info: WB: 1:1000~2000

Target Info

• Gene Symbol: H2AFX
• Gene Full Name: H2A histone family, member X
• Alias Symbols: H2A.X, H2A/X, H2AFX
• NCBI Gene Id: 3014; 15270;
• Description of Target: Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Required for checkpoint-mediated arrest of cell cycle progression in response to low doses of ionizing radiation and for efficient repair of DNA double strand breaks (DSBs) specifically when modified by C-terminal phosphorylation.
• Uniprot ID: P16104, P27661