GZMA Recombinant Protein (OPCD08056)

Catalog No: OPCD08056

GZMA Recombinant Protein (OPCD08056) using SDS-PAGE

Product Info

• Predicted Species Reactivity: Homo sapiens|Human
• Product Format: Freeze-dried Powder. PBS, pH7.4, containing 5% Trehalose.
• Host: Yeast
• Conjugation: Unconjugated
• Application: Ctrl (+), SDS-PAGE, WB
• Additional Information: Endotoxin Level: < 1.0 EU per 1 ug (determined by the LAL method)
  Residues: Ile29-Val262
  Subcellular Location: Secreted
• Reconstitution and Storage: 2°C to 8°C|-80°C
• Concentration: 200 ug/mL (prior to lyoph)
• Purity: > 95%
• Source: Yeast
• Tag: N-terminal His Tag

Target Info

• Gene Symbol: GZMA
• Gene Full Name: granzyme A
• Alias Symbols: CTL tryptase;CTLA3;cytotoxic T-lymphocyte proteinase 1;Cytotoxic T-lymphocyte-associated serine esterase-3;fragmentin-1;granzyme 1;granzyme A;Granzyme A (Cytotoxic T-lymphocyte-associated serine esterase-3; Hanukah factor serine protease);granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3);Granzyme-1;h factor;Hanukah factor serine protease);Hanukkah factor;HF;HFSP.
• NCBI Gene Id: 3001
• Protein Name: Granzyme A
• Description of Target: Abundant protease in the cytosolic granules of cytotoxic T-cells and NK-cells which activates caspase-independent cell death with morphological features of apoptosis when delivered into the target cell through the immunological synapse. It cleaves after Lys or Arg. Cleaves APEX1 after 'Lys-31' and destroys its oxidative repair activity. Cleaves the nucleosome assembly protein SET after 'Lys-189', which disrupts its nucleosome assembly activity and allows the SET complex to translocate into the nucleus to nick and degrade the DNA.
• Uniprot ID: P12544
• Protein Accession #: NP_006135.1
• Nucleotide Accession #: NM_006144.3
• Protein Size (# AA): Ile29~Val262
• Molecular Weight: 28kDa