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Catalog No: OPPA02226 (Formerly GWB-25FEBD)
Size:5UG
Price: $75.00
SKU
OPPA02226
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GSTM1 Protein (OPPA02226)

Datasheets/ManualsPrintable datasheet for OPPA02226
Product Info
Predicted Species ReactivityMouse
Product FormatThe GSTM1 solution contains 20 mM Tris-HCl buffer (pH8.0), 1mM DTT and 10% glycerol Physical appearance: Sterile Filtered colorless solution.
HostE. Coli
::Biological Activity: Specific activity is < 11 units/mg, and is defined as the amount of enzyme that conjugate 1.0 u mole of 1-chloro-2,4-dinitrobenzene (CDNB) with reduced glutathione per minute at pH 6.5 at 25C.
::Product Introduction: Cytosolic and membrane-bound types of GST are encoded by 2 different supergene families. There are 8 classes of the soluble cytoplasmic mammalian GST: alpha, kappa, mu, omega, pi, sigma, theta and zeta. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding the mu class of enzymes are arranged in a gene cluster on chromosome 1p13.3 and aare highly polymorphic. These genetic differences can change an individual's resistance to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs. Null mutations of this class mu gene have been linked with the rise in a number of cancers.
Product Description: GSTM1 Mouse Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 238 amino acids (1-218 a.a.) and having a molecular mass of 28.1kDa. The GTM1 is fused to a 20 amino acid His-Tag at N-Terminus and purified by proprietary chromatographic techniques.
Reconstitution and StorageGSTM1 although stable 4C for 4 weeks, should be stored desiccated below -18C. For long term storage it is recommended to add a carrier protein (0. 1% HSA or BSA). Please prevent freeze-thaw cycles.
PurityGreater than 95.0% as determined by SDS-PAGE.
Peptide SequenceMGSSHHHHHH SSGLVPRGSH MPMILGYWNV RGLTHPIRML LEYTDSSYDE KRYTMGDAPD FDRSQWLNEK FKLGLDFPNL PYLIDGSHKI TQSNAILRYL ARKHHLDGET EEERIRADIV ENQVMDTRMQ LIMLCYNPDF EKQKPEFLKT IPEKMKLYSE FLGKRPWFAG DKVTYVDFLA YDILDQYRMF EPKCLDAFPN LRDFLARFEG LKKISAYMKS SRYIATPIFS KMAHWSNK.
Gene SymbolGSTM1
Alias SymbolsGstb, Gstb-, Gstb1, Gstb-1
NCBI Gene Id14862
Protein NameGlutathione S-transferase Mu 1
Description of TargetRecombinant Mouse Glutathione S-Transferase M1 His-Tag
Uniprot IDP10649
Protein Accession #NP_034488.1
Protein Size (# AA)Recombinant
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