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Catalog No: OABB01264
Size:100UG
Price: $432.00
SKU
OABB01264
Availability: Domestic: within 1-2 week delivery | International: within 1-2 week delivery
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Datasheets/ManualsPrintable datasheet for GSN Antibody - C-terminal region (OABB01264)
Product Info
Tested Species ReactivityHuman, Mouse, Monkey, Rat
Predicted Species ReactivityBovine|Human|Monkey|Mouse|Rat
Product FormatLyophilized. Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
ClonalityPolyclonal
ClonePolyclonal
IsotypeRabbit IgG
HostRabbit
ApplicationFlow cytometry|Immunocytochemistry|Immunofluorescence|Immunohistochemistry|Western blot
Additional InformationNotes: WB: The detection limit for GSN is approximately 1.5ng/lane under reducing conditions.
Tested Species: In-house tested species with positive results.
By Heat: Boiling the paraffin sections in 10mM citrate buffer, pH6.0, for 20mins is required for the staining of formalin/paraffin sections.
Other applications have not been tested.
Optimal dilutions should be determined by end users.
::Background: Gelsolin also known as GNS is an actin-binding protein that is a key regulator of actin filament assembly and disassembly. Gelsolin is one of the most potent members of the actin-severing gelsolin/villin superfamily. The gene was assigned to human chromosome 9q33.2. Gelsolin is also known as brevin, or actin-depolymerizing factor; it is the principal intracellular and extracellular actin-severing protein. Gelsolin and Gc protein together constitute the extracellular actin-scavenger system which prevents the toxic effects of actin release into the extracellular space under circumstances of cell necrosis. Gelsolin may have therapeutic potential as a mucolytic agent in CF patients. The antiapoptotic activity of gelsolin seems to prevent a step leading to cytochrome c release from the mitochondria into the cytosol.
Reconstitution and Storage2°C to 8°C|-20°C
ImmunogenPolypeptide
PurificationAffinity Purified
Concentration500 ug/ml
SpecificityNo cross reactivity with other proteins.
Application InfoWestern blot: 0.1-0.5 ug/ml: Human, Monkey, Mouse, Rat
Immunohistochemistry (Paraffin-embedded Section): 0.5-1 ug/ml: Human, Rat: By Heat
Immunocytochemistry: 0.5-1 ug/ml: Mouse
Immunocytochemistry/Immunofluorescence: 2 ug/ml: Human
Flow Cytometry: 1-3 ug/1x10^6 cells: Human
Storage BufferEach vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
DescriptionRabbit IgG polyclonal antibody for Gelsolin(GSN) detection. Tested with WB, IHC-P, ICC, ICC/IF, FCM in Human;Mouse;Monkey;Rat.
Gene SymbolGSN
Gene Full Namegelsolin
Alias Symbolsactin-depolymerizing factor;ADF;AGEL;brevin;epididymis secretory sperm binding protein;gelsolin.
NCBI Gene Id2934
Protein NameGelsolin
Description of TargetCalcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). It can promote the assembly of monomers into filaments (nucleation) as well as sever filaments already formed. Plays a role in ciliogenesis.
Uniprot IDP06396
Molecular Weight85698 MW
  1. What is the species homology for "GSN Antibody - C-terminal region (OABB01264)"?

    The tested species reactivity for this item is "Human, Mouse, Monkey, Rat". This antibody is predicted to have homology to "Bovine|Human|Monkey|Mouse|Rat".

  2. How long will it take to receive "GSN Antibody - C-terminal region (OABB01264)"?

    This item is available "Domestic: within 1-2 week delivery | International: within 1-2 week delivery".

  3. What buffer format is "GSN Antibody - C-terminal region (OABB01264)" provided in?

    This item is provided in "Lyophilized. Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.".
    Additional format options may be available. For more information please contact info@avivasysbio.com.

  4. What are other names for "GSN Antibody - C-terminal region (OABB01264)"?

    This target may also be called "actin-depolymerizing factor;ADF;AGEL;brevin;epididymis secretory sperm binding protein;gelsolin." in publications.

  5. What is the shipping cost for "GSN Antibody - C-terminal region (OABB01264)"?

    The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.

  6. What is the guarantee for "GSN Antibody - C-terminal region (OABB01264)"?

    All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.

  7. Can I get bulk pricing for "GSN Antibody - C-terminal region (OABB01264)"?

    You can get bulk pricing for this item by going here.

  8. What is the molecular weight of the protein?

    The molecular weight reported by Uniprot for this item is "85698 MW".
    Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics.

  9. What protocols are available for "GSN Antibody - C-terminal region (OABB01264)"?

    We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data" tab on the product page.

  10. What are positive controls for "GSN"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  11. What are negative controls for "GSN"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  12. What other proteins interact with "GSN"?

    This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.

  13. What biological processes are associated with "GSN"?

    This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.

  14. What cellular components are associated with "GSN"?

    This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.

  15. What protein functions are associated with "GSN"?

    This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.

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