GSN Antibody - C-terminal region : HRP (ARP54299_P050-HRP)

Catalog No: ARP54299_P050-HRP

Size:100ul

Product Info

• Predicted Species Reactivity: Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Sheep, Zebrafish
• Product Format: Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6.
• Clonality: Polyclonal
• Host: Rabbit
• Conjugation: HRP: Horseradish Peroxidase
• Application: WB, IHC
• Reconstitution and Storage: All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil). Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.
• Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human GSN
• Purification: Affinity Purified
• Predicted Homology Based on Immunogen Sequence: Cow: 100%; Dog: 93%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 93%; Rabbit: 93%; Rat: 100%; Sheep: 100%; Zebrafish: 100%
• Peptide Sequence: Synthetic peptide located within the following region: KPMIIYKGGTSREGGQTAPASTRLFQVRANSAGATRAVEVLPKAGALNSN
• Concentration: 0.5 mg/ml
• Blocking Peptide: For anti-GSN (ARP54299_P050-HRP) antibody is Catalog # AAP54299 (Previous Catalog # AAPP31048)
• Reference: Shokouhi,G. Nephrol. Dial. Transplant. 23 (3), 1071 (2008)

Target Info

• Gene Symbol: GSN
• Gene Full Name: Gelsolin
• Alias Symbols: ADF, AGEL
• NCBI Gene Id: 2934
• Protein Name: Gelsolin
• Description of Target: GSN binds to the 'plus' ends of actin monomers and filaments to prevent monomer exchange. It is a calcium-regulated protein, which functions in both assembly and disassembly of actin filaments. Defects in the gene encoding GSN are a cause of familial amyloidosis Finnish type (FAF).The protein encoded by this gene binds to the 'plus' ends of actin monomers and filaments to prevent monomer exchange. The encoded calcium-regulated protein functions in both assembly and disassembly of actin filaments. Defects in this gene are a cause of familial amyloidosis Finnish type (FAF). Multiple transcript variants encoding several different isoforms have been found for this gene.
• Uniprot ID: P06396
• Protein Accession #: NP_000168
• Nucleotide Accession #: NM_000177
• Protein Size (# AA): 782
• Molecular Weight: 83kDa
• Protein Interactions: ITCH; CFLAR; TP53; UBC; CASP3; UBD; FN1; MPG; ESR1; ALB; SDHB; ACTA1; MDM2; UBE2Q2; FBXO25; ARRB2; ARRB1; AR; PSMD4; TNIK; CLIC5; TOM1L1; ACTN4; VDAC1; BCAR1; PXN; LIMK2; VASP; PIK3CG; PTK2B; FHIT; VCL; CSK; APP; ACTB; ACTG1; PLCG1; SRC; PTPN12; PTK2; PIK