- Gene Symbol:
- GSN
- NCBI Gene Id:
- 2934
- Official Gene Full Name:
- Gelsolin
- Protein Name:
- Gelsolin
- Swissprot Id:
- P06396
- Protein Accession #:
- NP_000168
- Nucleotide Accession #:
- NM_000177
- Alias Symbols:
- DKFZp313L0718, ADF, AGEL
- Replacement Item:
- This antibody may replace item sc-126909 from Santa Cruz Biotechnology.
- Description of Target:
- GSN binds to the 'plus' ends of actin monomers and filaments to prevent monomer exchange. It is a calcium-regulated protein, which functions in both assembly and disassembly of actin filaments. Defects in the gene encoding GSN are a cause of familial amyloidosis Finnish type (FAF).The protein encoded by this gene binds to the 'plus' ends of actin monomers and filaments to prevent monomer exchange. The encoded calcium-regulated protein functions in both assembly and disassembly of actin filaments. Defects in this gene are a cause of familial amyloidosis Finnish type (FAF). Multiple transcript variants encoding several different isoforms have been found for this gene.
- Protein Size (# AA):
- 782
- Molecular Weight:
- 83kDa
- Host:
- Rabbit
- Clonality:
- Polyclonal
- Purification:
- Affinity Purified
- Application:
- WB, IHC
- Tissue Tool:
- Find tissues and cell lines supported by DNA array analysis to express GSN.
- RNA Seq:
- Find tissues and cell lines supported by RNA-seq analysis to express GSN.
- Immunogen:
- The immunogen is a synthetic peptide directed towards the C terminal region of human GSN
- Tested Species Reactivity:
- Human
- Predicted Homology Based on Immunogen Sequence:
- Cow: 100%; Dog: 93%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 93%; Rabbit: 93%; Rat: 100%; Sheep: 100%; Zebrafish: 100%
- Complete computational species homology data:
- Anti-GSN (ARP54299_P050)
- Peptide Sequence:
- Synthetic peptide located within the following region: KPMIIYKGGTSREGGQTAPASTRLFQVRANSAGATRAVEVLPKAGALNSN
- Product Format:
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
- Reconstitution and Storage:
- For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
- Concentration:
- Batch dependent within range: 100 ul at 0.5 - 1 mg/ml
- Protein Interactions:
- ITCH; CFLAR; TP53; UBC; CASP3; UBD; FN1; MPG; ESR1; ALB; SDHB; ACTA1; MDM2; UBE2Q2; FBXO25; ARRB2; ARRB1; AR; PSMD4; TNIK; CLIC5; TOM1L1; ACTN4; VDAC1; BCAR1; PXN; LIMK2; VASP; PIK3CG; PTK2B; FHIT; VCL; CSK; APP; ACTB; ACTG1; PLCG1; SRC; PTPN12; PTK2; PIK
- Blocking Peptide:
- For anti-GSN (ARP54299_P050) antibody is Catalog # AAP54299 (Previous Catalog # AAPP31048)
- Datasheets/Manuals:
- Printable datasheet for anti-GSN (ARP54299_P050) antibody
- Target Reference:
- Shokouhi,G. Nephrol. Dial. Transplant. 23 (3), 1071 (2008)
Product Reviews
- Protocol:
- Tips Information:
See our General FAQ page.
