GSN Antibody - C-terminal region (ARP54299_P050)

Catalog#: ARP54299_P050

• Size: 100 ul

• Tested Species Reactivity: Human
• Predicted Species Reactivity: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Sheep, Zebrafish
• Product Format: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
• Clonality: Polyclonal
• Host: Rabbit
• Application: WB, IHC
• Reconstitution and Storage: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
• Replacement Item: This antibody may replace item sc-126909 from Santa Cruz Biotechnology.
• Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human GSN
• Purification: Affinity Purified
• Predicted Homology Based on Immunogen Sequence: Cow: 100%; Dog: 93%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 93%; Rabbit: 93%; Rat: 100%; Sheep: 100%; Zebrafish: 100%
• Peptide Sequence: Synthetic peptide located within the following region: KPMIIYKGGTSREGGQTAPASTRLFQVRANSAGATRAVEVLPKAGALNSN
• Concentration: Batch dependent within range: 100 ul at 0.5 - 1 mg/ml
• Blocking Peptide: For anti-GSN (ARP54299_P050) antibody is Catalog # AAP54299 (Previous Catalog # AAPP31048)
• Target Reference: Shokouhi,G. Nephrol. Dial. Transplant. 23 (3), 1071 (2008)
• Gene Symbol: GSN
• Official Gene Full Name: Gelsolin
• Alias Symbols: DKFZp313L0718, ADF, AGEL
• NCBI Gene Id: 2934
• Protein Name: Gelsolin
• Description of Target: GSN binds to the 'plus' ends of actin monomers and filaments to prevent monomer exchange. It is a calcium-regulated protein, which functions in both assembly and disassembly of actin filaments. Defects in the gene encoding GSN are a cause of familial amyloidosis Finnish type (FAF).The protein encoded by this gene binds to the 'plus' ends of actin monomers and filaments to prevent monomer exchange. The encoded calcium-regulated protein functions in both assembly and disassembly of actin filaments. Defects in this gene are a cause of familial amyloidosis Finnish type (FAF). Multiple transcript variants encoding several different isoforms have been found for this gene.
• Swissprot Id: P06396
• Protein Accession #: NP_000168
• Nucleotide Accession #: NM_000177
• Protein Size (# AA): 782
• Molecular Weight: 83kDa
• RNA Seq: Find tissues and cell lines supported by RNA-seq analysis to express GSN.
• Protein Interactions: ITCH; CFLAR; TP53; UBC; CASP3; UBD; FN1; MPG; ESR1; ALB; SDHB; ACTA1; MDM2; UBE2Q2; FBXO25; ARRB2; ARRB1; AR; PSMD4; TNIK; CLIC5; TOM1L1; ACTN4; VDAC1; BCAR1; PXN; LIMK2; VASP; PIK3CG; PTK2B; FHIT; VCL; CSK; APP; ACTB; ACTG1; PLCG1; SRC; PTPN12; PTK2; PIK

Protocol:

• Reconstitution Instructions
• Immunohistochemistry (IHC) Protocol
• Immunocytochemistry (ICC) Protocol
• Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
• Western Blotting/Immunoblotting (WB/IB) Protocol
• Blocking Peptide Competition Protocol (BPCP)
• Immunoprecipitation (IP) Protocol

Tips Information:

• IHC Tips & Tricks
• ICC Tips & Tricks
• ELISA Tips & Tricks
• WB/IB Tips & Tricks
• IP Tips & Tricks

See our General FAQ page.

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