GRIA2 Antibody (Phospho-Ser880) (OAAF00328)

Catalog No: OAAF00328 (Formerly GWB-ASB684)

Size:100 ug

Western blot analysis of extracts from mouse brain, using GluR2 (Phospho-Ser880) Antibody. The lane on the right is treated with the synthesized peptide.

Immunohistochemistry analysis of paraffin-embedded human brain, using GluR2 (Phospho-Ser880) Antibody. The picture on the right is treated with the synthesized peptide.

Product Info

• Predicted Species Reactivity: Human|Mouse|Rat
• Product Format: Liquid PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
• Clonality: Polyclonal
• Isotype: IgG
• Host: Rabbit
• Application: Enzyme-linked immunosorbent assay|Immunofluorescence|Immunohistochemistry|Immunohistochemistry-Paraffin|Western blot
• Reconstitution and Storage: -20°C
• Immunogen: The antiserum was produced against synthesized peptide derived from human GluR2 around the phosphorylation site of Ser880.
• Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Concentration: 1 mg/ml
• Specificity: Glutamate receptor 2 (phospho-Ser880) antibody detects endogenous levels of Glutamate receptor 2 only when phosphorylated at serine 880.
• Application Info: WB: 1/500 - 1/2000
  IHC: 1/100 - 1/300
  ELISA: 1/20000
• Reference: Kenneth J. Seidenman, J. Neurosci., Oct 2003; 23: 9220.
  Baosong Liu, J. Neurosci., May 2006; 26: 5309 - 5319.
  Jie Fu, J. Neurosci., Aug 2003; 23: 7592.
  Jose L. Perez, J. Neurosci., Aug 2001; 21: 5417.

Target Info

• Gene Symbol: GRIA2
• Gene Full Name: glutamate ionotropic receptor AMPA type subunit 2
• Alias Symbols: AMPA-selective glutamate receptor 2;GluA2;gluR-2;GLUR2;gluR-B;GLURB;GluR-K2;glutamate receptor 2;Glutamate receptor ionotropic, AMPA 2;glutamate receptor, ionotropic, AMPA 2;HBGR2;NEDLIB.
• NCBI Gene Id: 2891
• Protein Name: Glutamate receptor 2
• Description of Target: Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate. Through complex formation with NSG1, GRIP1 and STX12 controls the intracellular fate of AMPAR and the endosomal sorting of the GRIA2 subunit toward recycling and membrane targeting (By similarity).
• Uniprot ID: P42262
• Protein Accession #: NP_000817.2
• Molecular Weight: 98 kDa