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Catalog No: OAAB16489
Size:400ul
Price: $450.00
SKU
OAAB16489
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GREMLIN Antibody - C-terminal region (OAAB16489)

Datasheets/ManualsPrintable datasheet for OAAB16489
Product Info
Tested Species ReactivityHuman, Mouse
Predicted Species ReactivityRat
Product FormatLiquid. PBS with 0.09% (W/V) sodium azide
ClonalityPolyclonal
IsotypeIgG
HostRabbit
ApplicationIHC-P, WB
Additional InformationFunction: Cytokine that may play an important role during carcinogenesis and metanephric kidney organogenesis, as BMP a antagonist required for early limb outgrowth and patterning in maintaining the FGF4-SHH feedback loop. Down-regulates the BMP4 signaling in a dose- dependent manner. Antagonist of BMP2; inhibits BMP2-mediated differentiation of osteoblasts (in vitro) (By similarity). Acts as inhibitor of monocyte chemotaxis.
::Cellular Location: Secreted.
Tissue Location: Highly expressed in spleen and to a lesser extent in lung, skeletal muscle and kidney. Expressed only in non- transformed cells or primary fibroblasts in culture but not in established transformed or tumor derived cell lines. Broadly expressed in limb bud mesenchyme but restricted to the distal limb bud mesenchyme and concentrated posteriorly. Expressed in ovary especially in granulosa cells of follicles of type 4
Reconstitution and StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
ImmunogenThis GREMLIN antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 147-175 amino acids from the C-terminal region of mouse GREMLIN.
PurificationThis antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration0.45 mg/ml
Intended UseFor research use only and not for use in diagnostic or therapeutic procedures.
Application InfoWB~~1:2000
Optimal dilutions should be determined by the end user.
ReferenceChen, B., et al., J. Immunol. 173(10):5914-5917 (2004). Chen, B., et al., Biochem. Biophys. Res. Commun. 295(5):1135-1141 (2002). McMahon, R., et al., J. Biol. Chem. 275(14):9901-9904 (2000). Murphy, M., et al., J. Biol. Chem. 274(9):5830-5834 (1999). Hsu, D.R., et al., Mol. Cell 1(5):673-683 (1998).
Gene SymbolGrem1
Alias SymbolsDr, ld, Drm, gre, Grem, Cktsf1b, Cktsf1b1
NCBI Gene Id23892
Protein NameGremlin-1
Description of TargetGREMLIN is a member of the BMP (bone morphogenic protein) antagonist family. Like BMPs, BMP antagonists contain cystine knots and typically form homo- and heterodimers. The CAN (cerberus and dan) subfamily of BMP antagonists, to which this gene belongs, is characterized by a C-terminal cystine knot with an eight-membered ring. The antagonistic effect of the secreted glycosylated protein encoded by this gene is likely due to its direct binding to BMP proteins. As an antagonist of BMP, this gene may play a role in regulating organogenesis, body patterning, and tissue differentiation. In mouse, this protein has been shown to relay the sonic hedgehog (SHH) signal from the polarizing region to the apical ectodermal ridge during limb bud outgrowth.
Uniprot IDO70326
Protein Accession #NP_035954.1
Molecular Weight21 kDa
  1. What is the species homology for "GREMLIN Antibody - C-terminal region (OAAB16489)"?

    The tested species reactivity for this item is "Human, Mouse". This antibody is predicted to have homology to "Rat".

  2. How long will it take to receive "GREMLIN Antibody - C-terminal region (OAAB16489)"?

    This item is available "Domestic: within 1-2 week delivery | International: within 1-2 week delivery".

  3. What buffer format is "GREMLIN Antibody - C-terminal region (OAAB16489)" provided in?

    This item is provided in "Liquid. PBS with 0.09% (W/V) sodium azide".
    Additional format options may be available. For more information please contact info@avivasysbio.com.

  4. What are other names for "GREMLIN Antibody - C-terminal region (OAAB16489)"?

    This target may also be called "Dr, ld, Drm, gre, Grem, Cktsf1b, Cktsf1b1" in publications.

  5. What is the shipping cost for "GREMLIN Antibody - C-terminal region (OAAB16489)"?

    The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.

  6. What is the guarantee for "GREMLIN Antibody - C-terminal region (OAAB16489)"?

    All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.

  7. Can I get bulk pricing for "GREMLIN Antibody - C-terminal region (OAAB16489)"?

    You can get bulk pricing for this item by going here.

  8. What is the molecular weight of the protein?

    The molecular weight reported by Uniprot for this item is "21 kDa".
    Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics.

  9. What protocols are available for "GREMLIN Antibody - C-terminal region (OAAB16489)"?

    We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data" tab on the product page.

  10. What are positive controls for "GREM1"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  11. What are negative controls for "GREM1"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  12. What other proteins interact with "GREM1"?

    This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.

  13. What biological processes are associated with "GREM1"?

    This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.

  14. What cellular components are associated with "GREM1"?

    This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.

  15. What protein functions are associated with "GREM1"?

    This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.

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