GRAP2 Antibody (OAEE00404)

Catalog No: OAEE00404

Size:100UG

Product Info

• Predicted Species Reactivity: Human
• Product Format: Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
• Clonality: Monoclonal
• Clone: UW40
• Isotype: IgG2a
• Host: Mouse
• Application: Flow cytometry|Immunoprecipitation|Western blot
• Reconstitution and Storage: 2°C to 8°C
• Immunogen: GST-fusion human GRAP2/GADS protein
• Purification: Purified
• Concentration: 1 mg/ml
• Specificity: The mouse monoclonal antibody UW40 recognizes GRAP2/GADS, a 41 kDa cytoplasmic adaptor protein that plays a pivotal role during the early events of signal transduction in T cells.
• Formulation: Purified
• Purity: > 95% (by SDS-PAGE)
• Storage Buffer: Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4
• Reference: Yankee TM, Yun TJ, Draves KE, Ganesh K, Bevan MJ, Murali-Krishna K, Clark EA: The Gads (GrpL) adaptor protein regulates T cell homeostasis. J Immunol. 2004 Aug 1;173(3):1711-20.
  Yankee TM, Draves KE, Ewings MK, Clark EA, Graves JD: CD95/Fas induces cleavage of the GrpL/Gads adaptor and desensitization of antigen receptor signaling. Proc Natl Acad Sci U S A. 2001 Jun 5;98(12):6789-93.
  Dalheimer SL, Zeng L, Draves KE, Hassaballa A, Jiwa NN, Parrish TD, Clark EA, Yankee TM: Gads-deficient thymocytes are blocked at the transitional single positive CD4+stage. Eur J Immunol. 2009 May;39(5):1395-404.
  Cho S, Velikovsky CA, Swaminathan CP, Houtman JC, Samelson LE, Mariuzza RA: Structural basis for differential recognition of tyrosine-phosphorylated sites inthe linker for activation of T cells (LAT) by the adaptor Gads. EMBO J. 2004 Apr 7;23(7):1441-51
  Watanabe R, Harada Y, Takeda K, Takahashi J, Ohnuki K, Ogawa S, Ohgai D, Kaibara N, Koiwai O, Tanabe K, Toma H, Sugamura K, Abe R: Grb2 and Gads exhibit different interactions with CD28 and play distinct roles inCD28-mediated costimulation. J Immunol. 2006 Jul 15;177(2):1085-91.
  Moran O, Roessle MW, Mariuzza RA, Dimasi N: Structural features of the full-length adaptor protein GADS in solutiondetermined using small-angle X-ray scattering. Biophys J. 2008 Mar 1;94(5):1766-72.

Target Info

• Gene Symbol: GRAP2
• Gene Full Name: GRB2 related adaptor protein 2
• Alias Symbols: adapter protein GRID;GADS;GRAP-2;GRB2L;GRB-2-like protein;GRB2-related adapter protein 2;GRB2-related protein with insert domain;GRBLG;GrbX;grf-40;Grf40;grf40 adapter protein;GRID;growth factor receptor-binding protein;growth factor receptor-bound protein 2-related adaptor protein 2;GRPL;hematopoietic cell-associated adapter protein GrpL;hematopoietic cell-associated adaptor protein GRPL;Mona;P38;Protein GADS;SH3-SH2-SH3 adapter Mona;SH3-SH2-SH3 adaptor molecule.
• NCBI Gene Id: 9402
• Protein Name: GRB2-related adapter protein 2
• Description of Target: Interacts with SLP-76 to regulate NF-AT activation. Binds to tyrosine-phosphorylated shc.
• Uniprot ID: O75791
• Protein Accession #: NP_001278753.1; NP_001278754.1; NP_001278757.1; NP_004801.1
• Nucleotide Accession #: NM_001291824.1; NM_001291825.1; NM_001291828.1; NM_004810.3