Catalog No: OAAF00538 (Formerly GWB-ASB978)
Size:100 ug
Price: $344.00
SKU
OAAF00538
Availability: Domestic: within 1-2 week delivery | International: 1-2 weeks
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Datasheets/ManualsPrintable datasheet for GPS1 Antibody (Phospho-Ser454) (OAAF00538)
Product Info
Predicted Species ReactivityHuman|Mouse|Rat
Product FormatLiquid
ClonalityPolyclonal
HostRabbit
ApplicationEnzyme-linked immunosorbent assay|Immunofluorescence|Immunohistochemistry|Immunohistochemistry-Paraffin
Reconstitution and Storage-20°C
ImmunogenThe antiserum was produced against synthesized peptide derived from human COPS1 around the phosphorylation site of Ser454.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
SpecificityCOPS1 (Phospho-Ser454) antibody detects endogenous levels of COPS1 only when phosphorylated at serine 454.
FormulationRabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
DilutionThe optimal working dilution should be determined by the end user.
Application InfoIHC: 1:50~1:100; ELISA: 1:1000
ReferenceSpain B.H., Mol. Cell. Biol. 16:6698-6706(1996).
Ota T., Nat. Genet. 36:40-45(2004).
Seeger M., FASEB J. 12:469-478(1998).
Gene SymbolGPS1
Gene Full NameG protein pathway suppressor 1
Alias SymbolsCOP9 signalosome complex subunit 1;COPS1;CSN1;G protein pathway suppressor 1;JAB1-containing signalosome subunit 1;Protein MFH;SGN1.
NCBI Gene Id2873
Protein NameCOP9 signalosome complex subunit 1
Description of TargetEssential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Suppresses G-protein- and mitogen-activated protein kinase-mediated signal transduction.
Uniprot IDQ13098
Protein Accession #NP_004118.3
Molecular Weight53 kDa
  1. What is the species homology for "GPS1 Antibody (Phospho-Ser454) (OAAF00538)"?

    The tested species reactivity for this item is "". This antibody is predicted to have homology to "Human|Mouse|Rat".

  2. How long will it take to receive "GPS1 Antibody (Phospho-Ser454) (OAAF00538)"?

    This item is available "Domestic: within 1-2 week delivery | International: 1-2 weeks".

  3. What buffer format is "GPS1 Antibody (Phospho-Ser454) (OAAF00538)" provided in?

    This item is provided in "Liquid".
    Additional format options may be available. For more information please contact info@avivasysbio.com.

  4. What are other names for "GPS1 Antibody (Phospho-Ser454) (OAAF00538)"?

    This target may also be called "COP9 signalosome complex subunit 1;COPS1;CSN1;G protein pathway suppressor 1;JAB1-containing signalosome subunit 1;Protein MFH;SGN1." in publications.

  5. What is the shipping cost for "GPS1 Antibody (Phospho-Ser454) (OAAF00538)"?

    The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.

  6. What is the guarantee for "GPS1 Antibody (Phospho-Ser454) (OAAF00538)"?

    All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.

  7. Can I get bulk pricing for "GPS1 Antibody (Phospho-Ser454) (OAAF00538)"?

    You can get bulk pricing for this item by going here.

  8. What is the molecular weight of the protein?

    The molecular weight reported by Uniprot for this item is "53 kDa".
    Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics.

  9. What protocols are available for "GPS1 Antibody (Phospho-Ser454) (OAAF00538)"?

    We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data" tab on the product page.

  10. What are positive controls for "GPS1"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  11. What are negative controls for "GPS1"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  12. What other proteins interact with "GPS1"?

    This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.

  13. What biological processes are associated with "GPS1"?

    This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.

  14. What cellular components are associated with "GPS1"?

    This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.

  15. What protein functions are associated with "GPS1"?

    This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.

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