GPS1 Antibody (OABF01888)

Catalog No: OABF01888

Size:100UL

Lane 1: rat brain lysates Lane 2: human colon carcinoma lysates probed with Anti GPS1/CSN1 Polyclonal Antibody, Unconjugated (OABF01888) at 1:200 in 4C. Followed by conjugation to secondary antibody at 1:3000 90min in 37C. Predicted band 54kD. Observed band size: 54kD.

Formalin-fixed and paraffin embedded human lung carcinoma labeled with Anti-GPS1/CSN1 Polyclonal Antibody, Unconjugated (OABF01888) at 1:200 followed by conjugation to the secondary antibody and DAB staining

Product Info

• Predicted Species Reactivity: Human|Mouse|Rat
• Product Format: Liquid. Aqueous buffered solution containing 100ug/ml BSA, 50% glycerol and 0.09% sodium azide.
• Clonality: Polyclonal
• Isotype: IgG
• Host: Rabbit
• Conjugation: Unconjugated
• Application: Immunofluorescence|Immunohistochemistry-Paraffin|Western blot
• Additional Information: Subcellular location:
• Reconstitution and Storage: -20°C
• Immunogen: KLH conjugated synthetic peptide derived from human CSN1
• Purification: Protein A Purified
• Concentration: 1 ug/ul
• Application Info: WB: 1:100 - 1000
  IHC-P: : 1:100 - 500

Target Info

• Gene Symbol: GPS1
• Gene Full Name: G protein pathway suppressor 1
• Alias Symbols: COP9 signalosome complex subunit 1;COPS1;CSN1;G protein pathway suppressor 1;JAB1-containing signalosome subunit 1;Protein MFH;SGN1.
• NCBI Gene Id: 2873
• Protein Name: COP9 signalosome complex subunit 1
• Description of Target: Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Suppresses G-protein- and mitogen-activated protein kinase-mediated signal transduction.
• Uniprot ID: Q13098