GP2 Protein (OPPA00175)

Catalog No: OPPA00175

Size:2UG

Product Info

• Predicted Species Reactivity: Human
• Host: Sf9 insect cells.
  Product Introduction: Crohn's Disease (CD), which is very common in Caucasians, is an inflammatory bowel diseases (IBD). Mucosal inflammation in CD seems to arise when dysregulation of the immune system breaks the balance between tolerance to commensal microbiota or food-derived antigens and immunity to pathogens. The autoimmune mechanisms takes part in the development of CD, and exocrine pancreas autoantibodies (PAB) are disease-specific in CD patients. It was established not too long ago that glycoprotein 2 (GP2) is the major autoantigenic mark recognized by CD-specific PAB. Furthermore to IgG and IgM PAB isotypes, IgA pancreatic autoantibodies were also identified in CD patients. GP2 is an extremely glycosylated 78 kDa protein with N-linked carbohydrates. It is responsible for up to 40% of all zymogen granule (ZG) membrane proteins in pancreatic acinar cells and is linked to the ZG membrane via a glycosyl phosphoinositol (GPI) anchor.
  Product Description: GP2 is a cDNA coding for the free form of the human pancreatic secretory granule membrane major glycoprotein / GP2 having a molecular mass of 54,909 Dalton (protein component excluding glycosylation; observed molecular weight approx. 68 kDa) pH 5.4. GP2 protein is fused to a deca-histidine purification tag.
• Formulation: GP2 is supplied in 16mM HEPES buffer pH-8.0, 400mM NaCl, and 20% glycerol.
• Purification: Greater than 80% as determined by SDS-PAGE.
• Purity: Greater than 80% as determined by SDS-PAGE.
• Application Info: Western blot with monoclonal anti-GP2 antibodiesand monoclonal anti-hexa-His-tag antibody.

Target Info

• Gene Symbol: GP2
• Alias Symbols: Glycoprotein 2 (zymogen granule membrane), Pancreatic zymogen granule membrane protein GP-2, ZAP75, DKFZp779K0533.
• Protein Size (# AA): Recombinant