GP1BB Antibody - middle region (ARP82682_P050)

Catalog No: ARP82682_P050

Host: Rabbit
Target Name: GP1BB
Sample Tissue: Human RPMI 8226 Whole Cell lysates
Antibody Dilution: 1ug/ml

Product Info

• Tested Species Reactivity: Human
• Predicted Species Reactivity: Human
• Product Format: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
• Clonality: Polyclonal
• Host: Rabbit
• Application: WB
• Reconstitution and Storage: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
• Immunogen: The immunogen is a synthetic peptide directed towards the middle region of Human GP1BB
• Purification: Affinity purified
• Peptide Sequence: Synthetic peptide located within the following region: ALRTAHLGANPWRCDCRLVPLRAWLAGRPERAPYRDLRCVAPPALRGRLL
• Concentration: 0.5 mg/ml
• Blocking Peptide: For anti-GP1BB (ARP82682_P050) antibody is Catalog # AAP82682

Target Info

• Gene Symbol: GP1BB
• Gene Full Name: glycoprotein Ib platelet beta subunit
• Alias Symbols: BS, CD42C, GPIBB, BDPLT1, GPIbbeta
• NCBI Gene Id: 2812
• Protein Name: platelet glycoprotein Ib beta chain
• Description of Target: Platelet glycoprotein Ib (GPIb) is a heterodimeric transmembrane protein consisting of a disulfide-linked 140 kD alpha chain and 22 kD beta chain. It is part of the GPIb-V-IX system that constitutes the receptor for von Willebrand factor (VWF), and mediates platelet adhesion in the arterial circulation. GPIb alpha chain provides the VWF binding site, and GPIb beta contributes to surface expression of the receptor and participates in transmembrane signaling through phosphorylation of its intracellular domain. Mutations in the GPIb beta subunit have been associated with Bernard-Soulier syndrome, velocardiofacial syndrome and giant platelet disorder. The 206 amino acid precursor of GPIb beta is synthesized from a 1.0 kb mRNA expressed in plateletes and megakaryocytes. A 411 amino acid protein arising from a longer, unspliced transcript in endothelial cells has been described; however, the authenticity of this product has been questioned. Yet another less abundant GPIb beta mRNA species of 3.5 kb, expressed in nonhematopoietic tissues such as endothelium, brain and heart, was shown to result from inefficient usage of a non-consensus polyA signal in the neighboring upstream gene (SEPT5, septin 5). In the absence of polyadenylation from its own imperfect site, the SEPT5 gene produces read-through transcripts that use the consensus polyA signal of this gene.
• Uniprot ID: P13224
• Protein Accession #: NP_000398.1
• Nucleotide Accession #: NM_000407.4
• Protein Size (# AA): 206
• Molecular Weight: 22 kDa