GP1BA Antibody (OAEE00239)

Catalog No: OAEE00239

Size:100UG

Surface staining of human platelets with anti-CD42b (HIP1) PE.

Product Info

• Predicted Species Reactivity: Human|Non-human Primate
• Product Format: Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
• Clonality: Monoclonal
• Clone: HIP1
• Isotype: IgG1
• Host: Mouse
• Application: Flow cytometry|Immunohistochemistry-Frozen
• Reconstitution and Storage: 2°C to 8°C
• Immunogen: Peripheral blood mononuclear cells of a patient suffering with CLL.
• Purification: Purified
• Concentration: 1 mg/ml
• Specificity: The antibody HIP1 reacts with CD42b (GPIb alpha), a 135-145 kDa membrane glycoprotein expressed on platelets and megakaryocytes. CD42b and CD42c (GPIb beta) are composed in a disulfide linked heterodimer (CD42b/c; 160 kDa); CD42b/c forms a noncovalent complex with CD42a and CD42d.
  HLDA IV; WS Code P 40
• Formulation: Purified
• Purity: > 95% (by SDS-PAGE)
• Storage Buffer: Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4
• Reference: Takahashi R, Sekine N, Nakatake T: Influence of monoclonal antiplatelet glycoprotein antibodies on in vitro human megakaryocyte colony formation and proplatelet formation. Blood. 1999 Mar 15;93(6):1951-8.
  Leukocyte Typing IV., Knapp W et al. (Eds.), Oxford University Press (1989).
  Jain S, Zuka M, Liu J, Russell S, Dent J, Guerrero JA, Forsyth J, Maruszak B, Gartner TK, Felding-Habermann B, Ware J. Platelet glycoprotein Ib alpha supports experimental lung metastasis. Proc Natl Acad Sci U S A. 2007 May 22;104(21):9024-8.
  Vanhoorelbeke K, Ulrichts H, Van de Walle G, Fontayne A, Deckmyn H: Inhibition of platelet glycoprotein Ib and its antithrombotic potential. Curr Pharm Des. 2007;13(26):2684-97.
  Bergmeier W, Piffath CL, Goerge T, Cifuni SM, Ruggeri ZM, Ware J, Wagner DD: The role of platelet adhesion receptor GPIbalpha far exceeds that of its mainligand, von Willebrand factor, in arterial thrombosis. Proc Natl Acad Sci U S A. 2006 Nov 7;103(45):16900-5.

Target Info

• Gene Symbol: GP1BA
• Gene Full Name: glycoprotein Ib platelet subunit alpha
• Alias Symbols: antigen CD42b-alpha;BDPLT1;BDPLT3;BSS;CD42B;CD42b-alpha;DBPLT3;glycoprotein Ib (platelet), alpha polypeptide;glycoprotein Ib platelet alpha subunit;GP1B;GP-Ib alpha;GPIbA;GPIbalpha;mutant platelet membrane glycoprotein Ib-alpha;platelet glycoprotein Ib alpha chain;platelet membrane glycoprotein 1b-alpha subunit;platelet membrane glycoprotein Ib-alpha;VWDP.
• NCBI Gene Id: 2811
• Protein Name: Platelet glycoprotein Ib alpha chain
• Description of Target: GP-Ib, a surface membrane protein of platelets, participates in the formation of platelet plugs by binding to the A1 domain of vWF, which is already bound to the subendothelium.
• Uniprot ID: P07359
• Protein Accession #: NP_000164.5
• Nucleotide Accession #: NM_000173.6