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GOT1 Antibody - N-terminal region (ARP48205_P050)

100 ul

Regular Price: $319.00

Special Price: $229.00

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Conjugation Options

ARP48205_P050-FITC Conjugated

ARP48205_P050-HRP Conjugated

ARP48205_P050-Biotin Conjugated

Tested Species Reactivity:
Human
Predicted Species Reactivity:
Cow, Goat, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Yeast, Zebrafish
Product Format:
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Clonality:
Polyclonal
Host:
Rabbit
Application:
IHC, WB
Reconstitution and Storage:
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
Gene Symbol:
GOT1
Official Gene Full Name:
Glutamic-oxaloacetic transaminase 1, soluble (aspartate aminotransferase 1)
NCBI Gene Id:
2805
Protein Name:
Aspartate aminotransferase, cytoplasmic
Swissprot Id:
P17174
Protein Accession #:
NP_002070
Nucleotide Accession #:
NM_002079
Alias Symbols:
GIG18, ASTQTL1
Replacement Item:
This antibody may replace item sc-367196 from Santa Cruz Biotechnology.
Description of Target:
Glutamic-oxaloacetic transaminase is a pyridoxal phosphate-dependent enzyme which exists in cytoplasmic and mitochondrial forms, GOT1 and GOT2, respectively. GOT plays a role in amino acid metabolism and the urea and tricarboxylic acid cycles. The two enz
Protein Size (# AA):
413
Molecular Weight:
46kDa
Purification:
Affinity Purified
Tissue Tool:
Find tissues and cell lines supported by DNA array analysis to express GOT1.
RNA Seq:
Find tissues and cell lines supported by RNA-seq analysis to express GOT1.
Immunogen:
The immunogen is a synthetic peptide directed towards the N terminal region of human GOT1
Predicted Homology Based on Immunogen Sequence:
Cow: 100%; Goat: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Yeast: 92%; Zebrafish: 85%
Complete computational species homology data:
Anti-GOT1 (ARP48205_P050)
Peptide Sequence:
Synthetic peptide located within the following region: MAPPSVFAEVPQAQPVLVFKLTADFREDPDPRKVNLGVGAYRTDDCHPWV
Concentration:
Batch dependent within range: 100 ul at 0.5 - 1 mg/ml
Protein Interactions:
UBC; CHRAC1; SBDS; UBE2H; TYMS; MTAP; IDH1; HPRT1; ANXA6; ABI3BP; EGFR; TMEM120A; PC;
Blocking Peptide:
For anti-GOT1 (ARP48205_P050) antibody is Catalog # AAP48205 (Previous Catalog # AAPP13024)
Datasheets/Manuals:
Printable datasheet for anti-GOT1 (ARP48205_P050) antibody
Sample Type Confirmation:

GOT1 is supported by BioGPS gene expression data to be expressed in NCIH226

Target Reference:
Inoue,K., Diabetes Res. Clin. Pract. 79 (3), E4-E7 (2008)
Publications:

Povlsen, J. A. et al. Protection against myocardial ischemia-reperfusion injury at onset of type 2 diabetes in Zucker diabetic fatty rats is associated with altered glucose oxidation. PLoS One 8, e64093 (2013). IHC, WB, Cow, Goat, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Yeast, Zebrafish 23704975

Takeda, K., Ishida, A., Takahashi, K. & Ueda, T. Synaptic vesicles are capable of synthesizing the VGLUT substrate glutamate from -alpha-ketoglutarate for vesicular loading. J. Neurochem. 121, 184-96 (2012). IHC, WB, Cow, Goat, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Yeast, Zebrafish 22309504

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