Goat Anti-ATP6IP2 / Renin receptor Antibody (OAEB01325)

Catalog No: OAEB01325 (Formerly GWB-60ECDB)

Size:100UG

OAEB01325 staining (0.5ug/ml) of Human Kidney lysate (RIPA buffer, 35ug total protein per lane). Primary incubated for 1 hour. Detected by western blot using chemiluminescence.

Product Info

• Predicted Species Reactivity: Human|Rat
• Product Format: Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20°C. Minimize freezing and thawing.
• Clonality: Polyclonal
• Host: Goat
• Application: WB, IHC
• Reconstitution and Storage: Aliquot and store at -20C. Minimize freezing and thawing.
• Immunogen: ATP6AP2
• Purification: Ammonium Sulfate Precipitated; Affinity Purified
• Predicted Homology Based on Immunogen Sequence: Human, Rat
• Peptide Sequence: C-SIIYRMTNQKIRMD
• Concentration: 0.5 mg/ml
• Application Info: P-ELISA: Antibody detection limit dilution 1:16000
  WB: Approx 37 kDa band observed in Human Kidney lysates (calculated MW of 39.0kDa according to NP_005756.2). Recommended concentration: 0.25-1 ug/ml
  IHC: This antibody has been successfully used on Human tissue in the following papers: Pringle et al, J Renin Angiotensin Aldosterone Syst. 2010 Aug 11, PMID: 20702505. Delforce et al, Endocr Connect. 2017 Jan;6(1):9-19, PMID: 27956412.
• Reference: * Advani A, Kelly DJ, Cox AJ, White KE, Advani SL, Thai K, Connelly KA, Yuen D, Trogadis J, Herzenberg AM, Kuliszewski MA, Leong-Poi H, Gilbert RE.; The (Pro)renin receptor: site-specific and functional linkage to the vacuolar H+-ATPase in the kidney.; Hypertension. 2009 Aug;54(2):261-9.; Pubmed 19546380
  * Schefe JH, Neumann C, Goebel M, Danser J, Kirsch S, Gust R, Kintscher U, Unger T, Funke-Kaiser H.; Prorenin engages the (pro)renin receptor like renin and both ligand activities are unopposed by aliskiren.; J Hypertens. 2008 Sep;26(9):1787-94.; Pubmed 18698213
  * Kaneshiro Y, Ichihara A, Sakoda M, Takemitsu T, Nabi AH, Uddin MN, Nakagawa T, Nishiyama A, Suzuki F, Inagami T, Itoh H.; Slowly progressive, angiotensin II-independent glomerulosclerosis in human (pro)renin receptor-transgenic rats.; J Am Soc Nephrol. 2007 Jun;18(6):1789-95.; Pubmed 17494887
  * Ludwig J, Kerscher S, Brandt U, Pfeiffer K, Getlawi F, Apps DK, Schagger H.; Identification and characterization of a novel 9.2-kDa membrane sector-associated protein of vacuolar proton-ATPase from chromaffin granules.; J Biol Chem. 1998 May 1;273(18):10939-47.; Pubmed 9556572

Target Info

• Gene Symbol: Atp6ap2|ATP6AP2
• Gene Full Name: ATPase H+ transporting accessory protein 2|ATPase, H+ transporting, lysosomal accessory protein 2
• Alias Symbols: (P;(P)RR;5730403E06Rik;APT6M8-9;Atp;ATP6IP2;ATP6M8-9;ATPase H(+)-transporting lysosomal-interacting protein 2;ATPase, H+ transporting, lysosomal (vacuolar proton pump) membrane sector associated protein M8-9;ATPase, H+ transporting, lysosomal accessory protein 2;ATPase, H+ transporting, lysosomal interacting protein 1;ATPase, H+ transporting, lysosomal interacting protein 2;CDG2R;ELDF10;embryonic liver differentiation factor 10;ER-localized type I transmembrane adapter;ER-localized type I transmembrane adaptor;HT028;M8-9;MRXE;MRXSH;MSTP009;N14F;prorenin receptor;PRR;renin receptor;renin/prorenin receptor;RENR;vacuolar ATP synthase membrane sector-associated protein M8-9;vacuolar proton ATP synthase membrane sector associated protein M8-9;V-ATPase M8.9 subunit;XMRE;XPDS.
• NCBI Gene Id: 10159|70495
• Protein Name: Renin receptor
• Uniprot ID: O75787
• Protein Accession #: NP_005756.2
• Molecular Weight: 39