GMPS Antibody - middle region (ARP48619_P050)

Catalog No: ARP48619_P050

WB Suggested Anti-GMPS Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1:312500
Positive Control: MCF7 cell lysateGMPS is supported by BioGPS gene expression data to be expressed in MCF7

Product Info

• Tested Species Reactivity: Human
• Predicted Species Reactivity: Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Pig, Rabbit, Zebrafish
• Product Format: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
• Clonality: Polyclonal
• Host: Rabbit
• Application: WB
• Reconstitution and Storage: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
• Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human GMPS
• Purification: Affinity Purified
• Predicted Homology Based on Immunogen Sequence: Cow: 93%; Dog: 100%; Guinea Pig: 93%; Horse: 100%; Human: 100%; Mouse: 100%; Pig: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 93%
• Peptide Sequence: Synthetic peptide located within the following region: VCTALLNRALNQEQVIAVHIDNGFMRKRESQSVEEALKKLGIQVKVINAA
• Concentration: 0.5 mg/ml
• Blocking Peptide: For anti-GMPS (ARP48619_P050) antibody is Catalog # AAP48619 (Previous Catalog # AAPP35633)
• Sample Type Confirmation:

  GMPS is supported by BioGPS gene expression data to be expressed in MCF7

• Reference: Guo,D., (2005) Biochem. Biophys. Res. Commun. 337 (4), 1308-1318

Target Info

• Gene Symbol: GMPS
• Gene Full Name: Guanine monphosphate synthetase
• Alias Symbols: GATD7
• NCBI Gene Id: 8833
• Protein Name: GMP synthase [glutamine-hydrolyzing]
• Description of Target: In the de novo synthesis of purine nucleotides, IMP is the branch point metabolite at which point the pathway diverges to the synthesis of either guanine or adenine nucleotides. In the guanine nucleotide pathway, there are 2 enzymes involved in converting IMP to GMP, namely IMP dehydrogenase (IMPD1), which catalyzes the oxidation of IMP to XMP, and GMP synthetase, which catalyzes the amination of XMP to GMP.In the de novo synthesis of purine nucleotides, IMP is the branch point metabolite at which point the pathway diverges to the synthesis of either guanine or adenine nucleotides. In the guanine nucleotide pathway, there are 2 enzymes involved in converting IMP to GMP, namely IMP dehydrogenase (IMPD1), which catalyzes the oxidation of IMP to XMP, and GMP synthetase, which catalyzes the amination of XMP to GMP.
• Uniprot ID: P49915
• Protein Accession #: NP_003866
• Nucleotide Accession #: NM_003875
• Protein Size (# AA): 693
• Molecular Weight: 77kDa
• Protein Interactions: UBC; SUMO2; SUMO3; TNRC6B; SUMO1; NEDD8; COASY; EFHD2; PPME1; TSTA3; RCN1; RAB1A; PSMD5; PNP; MTAP; ENO2; FBXO6; AGPAT2; VCAM1; ITGA4; FN1; APRT; AHCY; CUL3; SIRT7; SUMO4; USP7; DDA1; PRKAG2; BABAM1; TCEAL1;