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Catalog No: OPPA00587 (Formerly GWB-5856C0)
Size:2UG
Price: $75.00
SKU
OPPA00587
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GM CSF Protein (OPPA00587)

Datasheets/ManualsPrintable datasheet for OPPA00587
Product Info
Predicted Species ReactivityHuman
Product FormatThe protein was lyophilized from a concentrated (1mg/ml) solution containing 10mM phosphate buffer pH 7.0, 40 mg mannitol and 10 mg sucrose. Physical appearance: Sterile Filtered White lyophilized (freeze-dried) powder.
HostPichia Pastoris
Additional InformationSolubility: It is recommended to reconstitute the lyophilized Granulocyte Macrophage Colony Stimulating Factor in sterile 18M Omega -cm H2O not less than 100 ug/ml, which can then be further diluted to other aqueous solutions.
::Biological Activity: The ED50 as determined by the dose-dependant stimulation of the proliferation of human TF-1 cells (human erythroleukemic indicator cell line) is < 0.183 ng/ml, corresponding to a Specific Activity of 5 x 106 IU/mg.
::Product Introduction: GMCSF is a cytokine that controls the production, differentiation, and function of granulocytes and macrophages. The active form of the protein is found extracellularly as a homodimer. This gene has been localized to a cluster of related genes at chromosome region 5q31, which is known to be associated with interstitial deletions in the 5q- syndrome and acute myelogenous leukemia. Other genes in the cluster include those encoding interleukins 4, 5, and 13.GM-CSF stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes.
Product Description: Granulocyte Macrophage Colony Stimulating Factor Human Recombinant produced in Yeast is a single, glycosylated, polypeptide chain containing 127 amino acids and having a molecular mass of 26-32 kDa. rhGMCSF differs from the natural human GM-CSF by a substitution of leucine at position 23 (R to L), and the carbohydrate moiety may be different from the native protein. GM-CSF is purified by proprietary chromatographic techniques.
Reconstitution and StorageLyophilized Granulocyte Macrophage Colony Stimulating Factor although stable at room temperature for 3 weeks, should be stored desiccated below -18C. Upon reconstitution GMCSF should be stored at 4C between 2-7 days and for future use below -18C. For long term storage it is recommended to add a carrier protein (0. 1% HSA or BSA). Please prevent freeze-thaw cycles.
PurityGreater than 97.0% as determined by1. Analysis by RP-HPLC.2. Analysis by SDS-PAGE.
Peptide SequenceThe sequence of the first five N - terminal amino acids was determined and was found to be Ala - Pro - Ala - Arg - Ser.
Gene SymbolGM CSF Pichia
Alias SymbolsCSF, GMCSF
NCBI Gene Id1437
Protein NameGranulocyte-macrophage colony-stimulating factor
Description of TargetRecombinant Human Granulocyte Macrophage-Colony Stimulating Factor, Pichia
Uniprot IDP04141
Protein Accession #NP_000749.2
Protein Size (# AA)Recombinant
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