Size:400ul
$320.00
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OAAB03686
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GLS2 Antibody - C-terminal region (OAAB03686)

Catalog#: OAAB03686
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More Information
Predicted Species Reactivity Human
Product Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Clonality Polyclonal
Isotype Rabbit Ig
Host Rabbit
Application WB, IHC, FC
Additional Information Function:Plays an important role in the regulation of glutamine catabolism. Promotes mitochondrial respiration and increases ATP generation in cells by catalyzing the synthesis of glutamate and alpha-ketoglutarate. Increases cellular anti-oxidant function via NADH and glutathione production. May play a role in preventing tumor proliferation.
:: Cellular Location: Mitochondrion.
Tissue Location: Highly expressed in liver. Expressed in brain and pancreas. Not observed in heart, placenta, lung, skeletal muscle and kidney. Expression is significantly reduced in hepatocellular carcinomas
Reconstitution and Storage Maintain refrigerated at 2-8C for up to 6 months. For long term storage store at -20C in small aliquots to prevent freeze-thaw cycles.
Replacement Item This antibody may replace item sc-168424 from Santa Cruz Biotechnology.
Predicted Homology Based on Immunogen Sequence Human
Datasheets/Manuals Printable datasheet for anti-GLS2 antibody - OAAB03686
Specificity This GLS2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 463~493 amino acids from the C-terminal region of human GLS2.
Application Info The suggested dilutions are:
Western Blot ~~ 1:1,000
Immunohistochemistry ~~ 1:10~50
Flow cytometry~~1:10~50
Other Applications Image 1 Data Flow cytometric analysis of K562 cells using GLS2 Antibody (C-term R471)(bottom histogram) compared to a negative control cell (top histogram)FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Publications

Shimmura, C. et al. Enzymes in the glutamate-glutamine cycle in the anterior cingulate cortex in postmortem brain of subjects with autism. Mol. Autism 4, 6 (2013). WB, IHC, FC, Human 23531457

Gene Symbol GLS2
Alias Symbols Glutaminase liver isoform, mitochondrial, GLS, L-glutamine amidohydrolase, L-glutaminase, GA, GLS2
NCBI Gene Id 27165
Protein Name Glutaminase liver isoform, mitochondrial
Swissprot Id Q9UI32
Protein Accession # NP_037399.2
Molecular Weight 66323 Da
Tissue Tool Find tissues and cell lines supported by DNA array analysis to express GLS2.
RNA Seq Find tissues and cell lines supported by RNA-seq analysis to express GLS2.
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