Size:400ul
$320.00
Discontinued
SKU
OAAB03686
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GLS2 Antibody - C-terminal region (OAAB03686)

Catalog#: OAAB03686
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Predicted Species Reactivity Human
Product Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Clonality Polyclonal
Isotype Rabbit Ig
Host Rabbit
Application WB, IHC, FC
Additional Information Function:Plays an important role in the regulation of glutamine catabolism. Promotes mitochondrial respiration and increases ATP generation in cells by catalyzing the synthesis of glutamate and alpha-ketoglutarate. Increases cellular anti-oxidant function via NADH and glutathione production. May play a role in preventing tumor proliferation.
:: Cellular Location: Mitochondrion.
Tissue Location: Highly expressed in liver. Expressed in brain and pancreas. Not observed in heart, placenta, lung, skeletal muscle and kidney. Expression is significantly reduced in hepatocellular carcinomas
Reconstitution and Storage Maintain refrigerated at 2-8C for up to 6 months. For long term storage store at -20C in small aliquots to prevent freeze-thaw cycles.
Replacement Item This antibody may replace item sc-168424 from Santa Cruz Biotechnology.
Predicted Homology Based on Immunogen Sequence Human
Datasheets/Manuals Printable datasheet for anti-GLS2 antibody - OAAB03686
Specificity This GLS2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 463~493 amino acids from the C-terminal region of human GLS2.
Application Info The suggested dilutions are:
Western Blot ~~ 1:1,000
Immunohistochemistry ~~ 1:10~50
Flow cytometry~~1:10~50
Other Applications Image 1 Data Flow cytometric analysis of K562 cells using GLS2 Antibody (C-term R471)(bottom histogram) compared to a negative control cell (top histogram)FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Publications

Shimmura, C. et al. Enzymes in the glutamate-glutamine cycle in the anterior cingulate cortex in postmortem brain of subjects with autism. Mol. Autism 4, 6 (2013). WB, IHC, FC, Human 23531457

Gene Symbol GLS2
Alias Symbols Glutaminase liver isoform, mitochondrial, GLS, L-glutamine amidohydrolase, L-glutaminase, GA, GLS2
NCBI Gene Id 27165
Protein Name Glutaminase liver isoform, mitochondrial
Swissprot Id Q9UI32
Protein Accession # NP_037399.2
Molecular Weight 66323 Da
Tissue Tool Find tissues and cell lines supported by DNA array analysis to express GLS2.
RNA Seq Find tissues and cell lines supported by RNA-seq analysis to express GLS2.
  1. What is the species homology for "GLS2 Antibody - C-terminal region (OAAB03686)"?

    The tested species reactivity for this item is "". This antibody is predicted to have homology to "Human".

  2. How long will it take to receive "GLS2 Antibody - C-terminal region (OAAB03686)"?

    This item is available "Domestic: within 1 week delivery | International: 1 week".

  3. What buffer format is "GLS2 Antibody - C-terminal region (OAAB03686)" provided in?

    This item is provided in "Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.".
    Additional format options may be available. For more information please contact info@avivasysbio.com.

  4. What are other names for "GLS2 Antibody - C-terminal region (OAAB03686)"?

    This target may also be called "Glutaminase liver isoform, mitochondrial, GLS, L-glutamine amidohydrolase, L-glutaminase, GA, GLS2" in publications.

  5. What is the shipping cost for "GLS2 Antibody - C-terminal region (OAAB03686)"?

    The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.

  6. What is the guarantee for "GLS2 Antibody - C-terminal region (OAAB03686)"?

    All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.

  7. Can I get bulk pricing for "GLS2 Antibody - C-terminal region (OAAB03686)"?

    You can get bulk pricing for this item by going here.

  8. What is the molecular weight of the protein?

    The molecular weight reported by Uniprot for this item is "66323 Da".
    Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics.

  9. What protocols are available for "GLS2 Antibody - C-terminal region (OAAB03686)"?

    We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data tab on the product page.

  10. What are positive controls for "GLS2"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  11. What are negative controls for "GLS2"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  12. What other proteins interact with "GLS2"?

    This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.

  13. What biological processes are associated with "GLS2"?

    This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.

  14. What cellular components are associated with "GLS2"?

    This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.

  15. What protein functions are associated with "GLS2"?

    This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.

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