- Gene Symbol:
- NCBI Gene Id:
- Protein Name:
- Glutaminase liver isoform, mitochondrial
- Swissprot Id:
- Protein Accession #:
- Alias Symbols:
- Glutaminase liver isoform, mitochondrial, GLS, L-glutamine amidohydrolase, L-glutaminase, GA, GLS2
- Replacement Item:
- This antibody may replace item sc-168424 from Santa Cruz Biotechnology.
- Molecular Weight:
- 66323 Da
- WB, IHC, FC
- Tissue Tool:
- Find tissues and cell lines supported by DNA array analysis to express GLS2.
- RNA Seq:
- Find tissues and cell lines supported by RNA-seq analysis to express GLS2.
- Predicted Homology Based on Immunogen Sequence:
- Product Format:
- Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
- Reconstitution and Storage:
- Maintain refrigerated at 2-8C for up to 6 months. For long term storage store at -20C in small aliquots to prevent freeze-thaw cycles.
- Printable datasheet for anti-GLS2 antibody - OAAB03686
- This GLS2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 463~493 amino acids from the C-terminal region of human GLS2.
- Rabbit Ig
- Application Info:
- The suggested dilutions are:
Western Blot ~~ 1:1,000
Immunohistochemistry ~~ 1:10~50
- Additional Information:
- Function:Plays an important role in the regulation of glutamine catabolism. Promotes mitochondrial respiration and increases ATP generation in cells by catalyzing the synthesis of glutamate and alpha-ketoglutarate. Increases cellular anti-oxidant function via NADH and glutathione production. May play a role in preventing tumor proliferation.
- Cellular Location: Mitochondrion.
Tissue Location: Highly expressed in liver. Expressed in brain and pancreas. Not observed in heart, placenta, lung, skeletal muscle and kidney. Expression is significantly reduced in hepatocellular carcinomas
Shimmura, C. et al. Enzymes in the glutamate-glutamine cycle in the anterior cingulate cortex in postmortem brain of subjects with autism. Mol. Autism 4, 6 (2013). WB, IHC, FC, Human 23531457