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Catalog No: OAAF02129 (Formerly GWB-ASD389)
Size:100 ug
Price: $344.00
SKU
OAAF02129
Availability: Domestic: within 1-2 week delivery | International: 1-2 weeks
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Datasheets/ManualsPrintable datasheet for GLI3 Antibody (OAAF02129)
Product Info
Predicted Species ReactivityHuman|Mouse|Rat
Product FormatLiquid
ClonalityPolyclonal
HostRabbit
ApplicationEnzyme-linked immunosorbent assay|Immunocytochemistry|Immunofluorescence|Immunohistochemistry-Paraffin
Reconstitution and Storage-20°C
ImmunogenThe antiserum was produced against synthesized peptide derived from human GLI-3.
PurificationThe antibody was purified from rabbit antiserum by affinity-chromatography using immunogen.
SpecificityGLI-3 antibody detects endogenous levels of total GLI-3 protein.
FormulationRabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
DilutionThe optimal working dilution should be determined by the end user.
Application InfoIHC: 1:50~1:100; IF: 1:100~1:500; ELISA: 1:20000
ReferenceHatch C.L., Nucleic Acids Res. 16:1113-1124(1988).
Hillier L.W., Nature 434:724-731(2005).
Jason L.J.M., Bioessays 24:166-174(2002).
Gene SymbolGLI3
Gene Full NameGLI family zinc finger 3
Alias SymbolsACLS;GCPS;GLI3 form of 190 kDa;GLI3 full-length protein;GLI3-190;GLI3FL;GLI-Kruppel family member GLI3;glioma-associated oncogene family zinc finger 3;oncogene GLI3;PAPA;PAP-A;PAPA1;PAPB;PHS;PPDIV;transcriptional activator GLI3;zinc finger protein GLI3.
NCBI Gene Id2737
Protein NameTranscriptional activator GLI3
Description of TargetHas a dual function as a transcriptional activator and a repressor of the sonic hedgehog (Shh) pathway, and plays a role in limb development. The full-length GLI3 form (GLI3FL) after phosphorylation and nuclear translocation, acts as an activator (GLI3A) while GLI3R, its C-terminally truncated form, acts as a repressor. A proper balance between the GLI3 activator and the repressor GLI3R, rather than the repressor gradient itself or the activator/repressor ratio gradient, specifies limb digit number and identity. In concert with TRPS1, plays a role in regulating the size of the zone of distal chondrocytes, in restricting the zone of PTHLH expression in distal cells and in activating chondrocyte proliferation. Binds to the minimal GLI-consensus sequence 5'-GGGTGGTC-3'.
Uniprot IDP10071
Protein Accession #NP_000159.3
Molecular Weight13 kDa
  1. What is the species homology for "GLI3 Antibody (OAAF02129)"?

    The tested species reactivity for this item is "". This antibody is predicted to have homology to "Human|Mouse|Rat".

  2. How long will it take to receive "GLI3 Antibody (OAAF02129)"?

    This item is available "Domestic: within 1-2 week delivery | International: 1-2 weeks".

  3. What buffer format is "GLI3 Antibody (OAAF02129)" provided in?

    This item is provided in "Liquid".
    Additional format options may be available. For more information please contact info@avivasysbio.com.

  4. What are other names for "GLI3 Antibody (OAAF02129)"?

    This target may also be called "ACLS;GCPS;GLI3 form of 190 kDa;GLI3 full-length protein;GLI3-190;GLI3FL;GLI-Kruppel family member GLI3;glioma-associated oncogene family zinc finger 3;oncogene GLI3;PAPA;PAP-A;PAPA1;PAPB;PHS;PPDIV;transcriptional activator GLI3;zinc finger protein GLI3." in publications.

  5. What is the shipping cost for "GLI3 Antibody (OAAF02129)"?

    The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.

  6. What is the guarantee for "GLI3 Antibody (OAAF02129)"?

    All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.

  7. Can I get bulk pricing for "GLI3 Antibody (OAAF02129)"?

    You can get bulk pricing for this item by going here.

  8. What is the molecular weight of the protein?

    The molecular weight reported by Uniprot for this item is "13 kDa".
    Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics.

  9. What protocols are available for "GLI3 Antibody (OAAF02129)"?

    We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data" tab on the product page.

  10. What are positive controls for "GLI3"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  11. What are negative controls for "GLI3"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  12. What other proteins interact with "GLI3"?

    This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.

  13. What biological processes are associated with "GLI3"?

    This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.

  14. What cellular components are associated with "GLI3"?

    This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.

  15. What protein functions are associated with "GLI3"?

    This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.

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