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GLI2 antibody - middle region (ARP31885_P050)

100 ul
$319.00
In Stock
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Conjugation Options

ARP31885_P050-FITC Conjugated

ARP31885_P050-HRP Conjugated

ARP31885_P050-Biotin Conjugated

Gene Symbol:
GLI2
NCBI Gene Id:
2736
Official Gene Full Name:
GLI family zinc finger 2
Protein Name:
Zinc finger protein GLI2
Swissprot Id:
P10070
Protein Accession #:
NP_084655
Nucleotide Accession #:
NM_030379
Alias Symbols:
HPE9, THP1, THP2
Replacement Item:
This antibody may replace item sc-20290 from Santa Cruz Biotechnology.
Description of Target:
GLI2 encodes a protein which belongs to the C2H2-type zinc finger protein subclass of the Gli family. Members of this subclass are characterized as transcription factors which bind DNA through zinc finger motifs. These motifs contain conserved H-C links. Gli family zinc finger proteins are mediators of Sonic hedgehog (Shh) signaling and they are implicated as potent oncogenes in the embryonal carcinoma cell. The protein encoded by this gene localizes to the cytoplasm and activates patched Drosophila homolog (PTCH) gene expression. It is also thought to play a role during embryogenesis. The encoded protein is associated with several phenotypes- Greig cephalopolysyndactyly syndrome, Pallister-Hall syndrome, preaxial polydactyly type IV, postaxial polydactyly types A1 and B.
Protein Size (# AA):
1258
Molecular Weight:
133kDa
Host:
Rabbit
Clonality:
Polyclonal
Purification:
Affinity Purified
Application:
IHC, WB
Tissue Tool:
Find tissues and cell lines supported by DNA array analysis to express GLI2.
RNA Seq:
Find tissues and cell lines supported by RNA-seq analysis to express GLI2.
Immunogen:
The immunogen is a synthetic peptide directed towards the N terminal region of human GLI2
Tested Species Reactivity:
Human, Mouse
Predicted Homology Based on Immunogen Sequence:
Human: 100%
Complete computational species homology data:
Anti-GLI2 (ARP31885_P050)
Peptide Sequence:
Synthetic peptide located within the following region: RNDVHLRTPLLKENGDSEAGTEPGGPESTEASSTSQAVEDCLHVRAIKTE
Product Format:
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution and Storage:
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
Concentration:
Batch dependent within range: 100 ul at 0.5 - 1 mg/ml
Protein Interactions:
SPOP; SKI; HDAC1; STK36; FBXW11; SUFU; ZIC2; ZIC1; CREB1; TBP;
Blocking Peptide:
For anti-GLI2 (ARP31885_P050) antibody is Catalog # AAP31885 (Previous Catalog # AAPP02680)
Datasheets/Manuals:
Printable datasheet for anti-GLI2 (ARP31885_P050) antibody
Target Reference:
Ikram,M.S., et al., (2004) J. Invest. Dermatol. 122 (6), 1503-1509
Publications:

Enzenhofer, E; Parzefall, T; Haymerle, G; Schneider, S; Kadletz, L; Heiduschka, G; Pammer, J; Oberndorfer, F; Wrba, F; Loader, B; Grasl, MC; Perisanidis, C; Erovic, BM; Impact of Sonic Hedgehog Pathway Expression on Outcome in HPV Negative Head and Neck Carcinoma Patients after Surgery and Adjuvant Radiotherapy. 11, e0167665 (2016). IHC, WB, Human 27918595

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