GHBP Protein (OPPA00729)

Catalog No: OPPA00729 (Formerly GWB-67FD3C)

Size:5UG

Product Info

• Predicted Species Reactivity: Sheep
• Product Format: GHBP was lyophilized from a concentrated (1mg/ml) solution with 0.0045mM NaHCO3. Physical appearance: Sterile Filtered White lyophilized (freeze-dried) powder.
• Host: E. Coli
• Additional Information: Solubility: It is recommended to reconstitute the lyophilized Growth Hormone Binding Protein in sterile 18M Omega -cm H2O not less than 100 ug/ml, which can then be further diluted to other aqueous solutions.
  Product Introduction: GHBP is a transmembrane receptor for growth hormone. Binding of growth hormone to the receptor leads to receptor dimerization and the activation of an intra- and intercellular signal transduction pathway leading to growth. A common alternate allele of this gene, called GHRd3, lacks exon three and has been well-characterized. Mutations in this gene have been associated with Laron syndrome, also known as the growth hormone insensitivity syndrome (GHIS), a disorder characterized by short stature. Other splice variants, including one encoding a soluble form of the protein (GHRtr), have been observed but have not been thoroughly characterized.
  Product Description: Growth Hormone Binding Protein Ovine Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 237 amino acids and having a molecular mass of 28 kDa. GHBP is purified by proprietary chromatographic techniques.
• Reconstitution and Storage: Lyophilized Growth Hormone Binding Protein although stable at room temperature for 3 weeks, should be stored desiccated below -18C. Upon reconstitution GHBP should be stored at 4C between 2-7 days and for future use below -18C. For long term storage it is recommended to add a carrier protein (0. 1% HSA or BSA). Please prevent freeze-thaw cycles.
• Purity: Greater than 95.0% as determined by (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.
• Peptide Sequence: The sequence of the first five N - terminal amino acids was determined and was found to be Ala - Phe - Ser - Gly - Ser.

Target Info

• Gene Symbol: oGHBP
• Alias Symbols: GHR, GHBP, GH receptor, Somatotropin receptor, GHBP Ovine, Growth Hormone Binding Protein Ovine Recombinant
• NCBI Gene Id: 443333
• Protein Name: Growth hormone receptor
• Description of Target: Recombinant Ovine Growth Hormone Binding Protein
• Uniprot ID: Q28575
• Protein Accession #: NP_001009323.1
• Protein Size (# AA): Recombinant