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GH Antibody (OAAD00159)

100 ug
$255.00
In Stock
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Predicted Species Reactivity:
Human
Clonality:
Monoclonal
Clone:
GH-15
Isotype:
IgG1
Host:
Mouse
Application:
IHC, IP
Reconstitution and Storage:
At -20C for one year. After reconstitution, at 4C for one month. It can also be aliquotted and stored frozen at -20C for longer time.
Gene Symbol:
GH1
NCBI Gene Id:
2688
Protein Name:
Somatotropin
Swissprot Id:
P01241
Alias Symbols:
GH, GHN, GH-N, hGH-N, IGHD1B,
Replacement Item:
This antibody may replace item sc-10364 from Santa Cruz Biotechnology.
Description of Target:
Growth Hormone (GH) is mapped to 17q22-q24. Human growth hormone has a molecular mass of 22, 005 and contains 191 amino acid residues with 2 disulfide bridges. It binds two receptor molecules and thereby induces signal transduction through receptor dimerization. At high concentrations, GH acts as an antagonist because of a large difference in affinities at the respective binding sites.
Purification:
Purified by the goat anti-mouse IgG Affinity chromatography.
Tissue Tool:
Find tissues and cell lines supported by DNA array analysis to express GH1.
RNA Seq:
Find tissues and cell lines supported by RNA-seq analysis to express GH1.
Immunogen:
Recombinant hGH.
Datasheets/Manuals:
Printable datasheet for GH Antibody (OAAD00159) - OAAD00159
Specificity:
Human.
No cross reactivity with other proteins.
Formulation:
Lyophilized from 1.2% sodium acetate, with 2mg BSA and 0.01mg NaN3 as preservative.
Application Info:
Immunohistochemistry(P) At 2-4ug/ml to detect growth hormone in formalin fixed and paraffin embedded tissues.
Other applications have not been tested.
Optimal dilutions should be determined by end user.
Storage Buffer:
1.2% sodium acetate or neutral PBS. If 1ml of PBS is used, the antibody concentration will be 100ug/ml.
Target Reference:
1. Niall, H. D.; Hogan, M. L.; Sauer, R.; Rosenblum, I. Y.; Greenwood, F. C. : Sequence of pituitary and placental lactogenic and growth hormones: evolution from a primordial peptide by gene reduplication.
Proc. Nat. Acad. Sci. 68: 866-869, 1971.
2. Sundstrom, M.; Lundqvist, T.; Rodin, J.; Giebel, L. B.; Milligan, D.; Norstedt, G. : Crystal structure of an antagonist mutant of human growth hormone, G120R, in complex with its receptor at 2.9 angstrom resolution. J. Biol. Chem. 271: 32197-32203, 1996.

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