GDF15 Recombinant Protein (OPCD03490)

Catalog No: OPCD03490

GDF15 Recombinant Protein (OPCD03490) using SDS-PAGE

GDF15 Recombinant Protein (OPCD03490) using SDS-PAGE

Product Info

• Predicted Species Reactivity: Mouse|Mus musculus
• Product Format: Freeze-dried Powder. PBS, pH7.4, containing 0.01% SKL, 5% Trehalose.
• Host: E.coli
• Conjugation: Unconjugated
• Application: Positive control|Sodium sodecyl sulfate - polyacrylamide gel electrophoresis|Western blot
• Additional Information: Endotoxin Level: < 1.0 EU per 1 ug (determined by the LAL method)
  Residues: His193-Val296
  Subcellular Location: Secreted
• Reconstitution and Storage: 2°C to 8°C|-80°C
• Concentration: 200 ug/mL (prior to lyoph)
• Purity: > 95%
• Source: E.coli
• Tag: N-terminal His Tag

Target Info

• Gene Symbol: Gdf15
• Gene Full Name: growth differentiation factor 15
• Alias Symbols: growth/differentiation factor 15;macrophage inhibiting cytokine-1;macrophage inhibitory cytokine 1;MIC-;MIC-1;NAG;NAG-1;SBF.
• NCBI Gene Id: 23886
• Protein Name: Growth/differentiation factor 15
• Description of Target: Regulates food intake, energy expenditure and body weight in response to metabolic and toxin-induced stresses. Binds to its receptor, GFRAL, and activates GFRAL-expressing neurons localized in the area postrema and nucleus tractus solitarius of the brainstem. It then triggers the activation of neurons localized within the parabrachial nucleus and central amygdala, which contitutes part of the 'emergency circuit' that shapes feeding responses to stressful conditions (PubMed:28953886, PubMed:28846097, PubMed:28846099, PubMed:28572090, PubMed:23468844, PubMed:29046435). On hepatocytes, inhibits growth hormone signaling (PubMed:28572090).
• Uniprot ID: Q9Z0J7
• Protein Accession #: NP_035949.2
• Nucleotide Accession #: NM_011819.3
• Protein Size (# AA): His193~Val296
• Molecular Weight: 20kDa