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GCLC Recombinant Protein (OPCD03466)

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Gene Symbol:
GCLC
Official Gene Full Name:
glutamate-cysteine ligase catalytic subunit
Alias Symbols:
Gamma-ECS, Gamma-glutamylcysteine synthetase, GCL, GCS, GCS heavy chain, GLCL, GLCLC, Glutamate--cysteine ligase catalytic subunit
NCBI Gene Id:
2729
Swissprot Id:
P48506
Protein Accession #:
NP_001184044.1
Nucleotide Accession #:
NM_001197115.1
Protein Name:
Glutamate--cysteine ligase catalytic subunit
Description of Target:
Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase is the first rate-limiting enzyme of glutathione synthesis. The enzyme consists of two subunits, a heavy catalytic subunit and a light regulatory subunit. This locus encodes the catalytic subunit, while the regulatory subunit is derived from a different gene located on chromosome 1p22-p21. Mutations at this locus have been associated with hemolytic anemia due to deficiency of gamma-glutamylcysteine synthetase and susceptibility to myocardial infarction.
Host:
E.coli
Conjugation:
Unconjugated
Molecular Weight:
25 kDa
Tissue Tool:
Find tissues and cell lines supported by DNA array analysis to express GCLC.
RNA Seq:
Find tissues and cell lines supported by RNA-seq analysis to express GCLC.
Product Format:
Lyophilized
Predicted Species Reactivity:
Human
Formulation:
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
Purity:
> 95%
Source:
Prokaryotic Expressed Recombinant
Application:
SDS-PAGE, WB, ELISA, IP
Additional Information:
Endotoxin Level: < 1.0 EU per 1 ug (determined by the LAL method)
:::
Residues: Met429-Asn637
Tag:
N-terminal His Tag
Reconstitution and Storage:
Reconstitute in PBS or others.
Store at 2-8C for one month. Aliquot and store at -80C for 12 months. Avoid repeated freeze/thaw cycles.
Datasheets/Manuals:
Printable datasheet for OPCD03466

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