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OPCD03466
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GCLC Recombinant Protein (OPCD03466)

Catalog#: OPCD03466
Domestic: within 1-2 weeks delivery | International: 1-2 weeks
More Information
Predicted Species Reactivity Human
Product Format Lyophilized
Host E.coli
Conjugation Unconjugated
Application SDS-PAGE, WB, ELISA, IP
Additional Information Endotoxin Level: < 1.0 EU per 1 ug (determined by the LAL method)
:: Residues: Met429-Asn637
Reconstitution and Storage Reconstitute in PBS or others.
Store at 2-8C for one month. Aliquot and store at -80C for 12 months. Avoid repeated freeze/thaw cycles.
Formulation PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
Purity > 95%
Source Prokaryotic Expressed Recombinant
Tag N-terminal His Tag
Datasheets/Manuals Printable datasheet for OPCD03466
Gene Symbol GCLC
Official Gene Full Name glutamate-cysteine ligase catalytic subunit
Alias Symbols Gamma-ECS, Gamma-glutamylcysteine synthetase, GCL, GCS, GCS heavy chain, GLCL, GLCLC, Glutamate--cysteine ligase catalytic subunit
NCBI Gene Id 2729
Protein Name Glutamate--cysteine ligase catalytic subunit
Description of Target Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase is the first rate-limiting enzyme of glutathione synthesis. The enzyme consists of two subunits, a heavy catalytic subunit and a light regulatory subunit. This locus encodes the catalytic subunit, while the regulatory subunit is derived from a different gene located on chromosome 1p22-p21. Mutations at this locus have been associated with hemolytic anemia due to deficiency of gamma-glutamylcysteine synthetase and susceptibility to myocardial infarction.
Swissprot Id P48506
Protein Accession # NP_001184044.1
Nucleotide Accession # NM_001197115.1
Molecular Weight 25 kDa
Tissue Tool Find tissues and cell lines supported by DNA array analysis to express GCLC.
RNA Seq Find tissues and cell lines supported by RNA-seq analysis to express GCLC.
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