- Predicted Species Reactivity:
- Mouse, Human
- Product Format:
- Liquid
- Clonality:
- Polyclonal
- Host:
- Rabbit
- Conjugation:
- KLH: Keyhole Limpet Hemocyanin
- Application:
- IHC-P, WB
- Reconstitution and Storage:
- For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
- Official Gene Full Name:
- glutamate-cysteine ligase catalytic subunit
- NCBI Gene Id:
- 2729
- Protein Name:
- glutamate--cysteine ligase catalytic subunit
- Alias Symbols:
- GCLC, GCL, GCS heavy chain, Gamma-ECS, GCS, GLCL, GLCLC
- Replacement Item:
- This antibody may replace item sc-115522 from Santa Cruz Biotechnology.
- Description of Target:
- Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase is the first rate-limiting enzyme of glutathione synthesis. The enzyme consists of two subunits, a heavy catalytic subunit and a light regulatory subunit. This locus encodes the catalytic subunit, while the regulatory subunit is derived from a different gene located on chromosome 1p22-p21. Mutations at this locus have been associated with hemolytic anemia due to deficiency of gamma-glutamylcysteine synthetase and susceptibility to myocardial infarction.
- Purification:
- Immunoaffinity purified
- Tissue Tool:
- Find tissues and cell lines supported by DNA array analysis to express GCLC.

- RNA Seq:
- Find tissues and cell lines supported by RNA-seq analysis to express GCLC.

- Immunogen:
- KLH-conjugated synthetic peptide from internal region of human GCLC.
- Preservative:
- 0.09% sodium azide