GCLC Antibody (OALA08635)

Catalog#: OALA08635

• Size: 200 uL

• Predicted Species Reactivity: Mouse, Human
• Product Format: Liquid
• Clonality: Polyclonal
• Host: Rabbit
• Conjugation: KLH: Keyhole Limpet Hemocyanin
• Application: IHC-P, WB
• Reconstitution and Storage: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
• Gene Symbol: GCLC
• Official Gene Full Name: glutamate-cysteine ligase catalytic subunit
• NCBI Gene Id: 2729
• Protein Name: glutamate--cysteine ligase catalytic subunit
• Swissprot Id: P48506
• Protein Accession #: NP_001184044.1
• Nucleotide Accession #: NM_001197115.1
• Alias Symbols: GCLC, GCL, GCS heavy chain, Gamma-ECS, GCS, GLCL, GLCLC
• Replacement Item: This antibody may replace item sc-115522 from Santa Cruz Biotechnology.
• Description of Target: Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase is the first rate-limiting enzyme of glutathione synthesis. The enzyme consists of two subunits, a heavy catalytic subunit and a light regulatory subunit. This locus encodes the catalytic subunit, while the regulatory subunit is derived from a different gene located on chromosome 1p22-p21. Mutations at this locus have been associated with hemolytic anemia due to deficiency of gamma-glutamylcysteine synthetase and susceptibility to myocardial infarction.
• Purification: Immunoaffinity purified
• RNA Seq: Find tissues and cell lines supported by RNA-seq analysis to express GCLC.
• Immunogen: KLH-conjugated synthetic peptide from internal region of human GCLC.
• Preservative: 0.09% sodium azide
• Formulation: PBS, 0.09% sodium azide

Protocol:

Tips Information: