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GCLC Antibody (OALA08635)

200 uL
$539.00
In Stock
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Predicted Species Reactivity:
Mouse, Human
Product Format:
Liquid
Clonality:
Polyclonal
Host:
Rabbit
Conjugation:
KLH: Keyhole Limpet Hemocyanin
Application:
IHC-P, WB
Reconstitution and Storage:
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
Gene Symbol:
GCLC
Official Gene Full Name:
glutamate-cysteine ligase catalytic subunit
NCBI Gene Id:
2729
Protein Name:
glutamate--cysteine ligase catalytic subunit
Swissprot Id:
P48506
Protein Accession #:
NP_001184044.1
Nucleotide Accession #:
NM_001197115.1
Alias Symbols:
GCLC, GCL, GCS heavy chain, Gamma-ECS, GCS, GLCL, GLCLC
Replacement Item:
This antibody may replace item sc-115522 from Santa Cruz Biotechnology.
Description of Target:
Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase is the first rate-limiting enzyme of glutathione synthesis. The enzyme consists of two subunits, a heavy catalytic subunit and a light regulatory subunit. This locus encodes the catalytic subunit, while the regulatory subunit is derived from a different gene located on chromosome 1p22-p21. Mutations at this locus have been associated with hemolytic anemia due to deficiency of gamma-glutamylcysteine synthetase and susceptibility to myocardial infarction.
Purification:
Immunoaffinity purified
Tissue Tool:
Find tissues and cell lines supported by DNA array analysis to express GCLC.
RNA Seq:
Find tissues and cell lines supported by RNA-seq analysis to express GCLC.
Immunogen:
KLH-conjugated synthetic peptide from internal region of human GCLC.
Datasheets/Manuals:
Printable datasheet for anti-GCLC (OALA08635) antibody
Preservative:
0.09% sodium azide
Formulation:
PBS, 0.09% sodium azide

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