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GCLC Antibody (OABB01646)

100 ug
$375.00
In Stock
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Predicted Species Reactivity:
Human, Rat
Product Format:
Lyophilized. Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.
Clonality:
Polyclonal
Isotype:
IgG
Host:
Rabbit
Application:
WB, IHC-P
Reconstitution and Storage:
Add 0.2ml of distilled water will yield a concentration of 500ug/ml. Store at -20C for one year. After reconstitution, at 4C for one month. It can also be aliquotted and stored frozen at -20C for a longer time. Avoid repeated freezing and thawing.
Gene Symbol:
GCLC
Official Gene Full Name:
Glutamate--cysteine ligase catalytic subunit
NCBI Gene Id:
2729
Swissprot Id:
P48506
Alias Symbols:
EC 6.3.2.2, Gamma ECS, Gamma GCS, Gamma glutamylcysteine synthetase, Gamma-ECS, Gamma-glutamylcysteine synthetase, GCL, GCLC, GCLM, GCS, GCS Heavy Chain, GLCL, GLCLC, GLCLR, Glutamate cysteine ligase catalytic subunit, Glutamate cysteine ligase (gamma glu
Replacement Item:
This antibody may replace item sc-115522 from Santa Cruz Biotechnology.
Description of Target:
GCLC, also named Glutamate--cysteine ligase catalytic subunit, is an enzyme that in humans is encoded by the GCLC gene. Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase is the first rate limiting enzyme of glutathione synthesis. The enzyme consists of two subunits, a heavy catalytic subunit and a light regulatory subunit. The gene encoding the catalytic subunit encodes a protein of 367 amino acids with a calculated molecular weight of 72.773 kDa and maps to chromosome 6p12.1. Deficiency of gamma-glutamylcysteine synthetase in human is associated with enzymopathic hemolytic anemia.
Purification:
Immunogen affinity purified.
Tissue Tool:
Find tissues and cell lines supported by DNA array analysis to express GCLC.
RNA Seq:
Find tissues and cell lines supported by RNA-seq analysis to express GCLC.
Immunogen:
E.coli-derived human GCLC recombinant protein (Position: E437-N637). Human GCLC shares 94% amino acid (aa) sequence identity with both mouse and rat GCLC.
Datasheets/Manuals:
Printable datasheet for anti-GCLC (OABB01646) antibody
Application Info:
WB: 0.1-0.5ug/ml
IHC-P: 0.5-1ug/ml

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