Size:100 ug
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More Information
Predicted Species ReactivityHuman, Rat
Product FormatLyophilized. Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.
ApplicationWB, IHC-P
Reconstitution and StorageAdd 0.2ml of distilled water will yield a concentration of 500ug/ml. Store at -20C for one year. After reconstitution, at 4C for one month. It can also be aliquotted and stored frozen at -20C for a longer time. Avoid repeated freezing and thawing.
Replacement ItemThis antibody may replace item sc-115522 from Santa Cruz Biotechnology.
ImmunogenE.coli-derived human GCLC recombinant protein (Position: E437-N637). Human GCLC shares 94% amino acid (aa) sequence identity with both mouse and rat GCLC.
PurificationImmunogen affinity purified.
Datasheets/ManualsPrintable datasheet for anti-GCLC (OABB01646) antibody
Application InfoWB: 0.1-0.5ug/ml
IHC-P: 0.5-1ug/ml
Gene SymbolGCLC
Official Gene Full NameGlutamate--cysteine ligase catalytic subunit
Alias SymbolsEC, Gamma ECS, Gamma GCS, Gamma glutamylcysteine synthetase, Gamma-ECS, Gamma-glutamylcysteine synthetase, GCL, GCLC, GCLM, GCS, GCS Heavy Chain, GLCL, GLCLC, GLCLR, Glutamate cysteine ligase catalytic subunit, Glutamate cysteine ligase (gamma glu
NCBI Gene Id2729
Description of TargetGCLC, also named Glutamate--cysteine ligase catalytic subunit, is an enzyme that in humans is encoded by the GCLC gene. Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase is the first rate limiting enzyme of glutathione synthesis. The enzyme consists of two subunits, a heavy catalytic subunit and a light regulatory subunit. The gene encoding the catalytic subunit encodes a protein of 367 amino acids with a calculated molecular weight of 72.773 kDa and maps to chromosome 6p12.1. Deficiency of gamma-glutamylcysteine synthetase in human is associated with enzymopathic hemolytic anemia.
Swissprot IdP48506
Tissue ToolFind tissues and cell lines supported by DNA array analysis to express GCLC.
RNA SeqFind tissues and cell lines supported by RNA-seq analysis to express GCLC.
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