Size:100 ug
$269.00
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SKU
OABB00446
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GCLC Antibody (OABB00446)

Catalog#: OABB00446
Domestic: within 1 week delivery | International: 1 week
This product is Genway GWB-BBP369
More Information
Predicted Species Reactivity Human, Mouse, Rat
Product Format Lyophilized
Clonality Polyclonal
Application WB, IHC-P
Additional Information Content: Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3
:: Background: GCLC, Glutamate--cysteine ligase catalytic subunit, is an enzyme that in humans is encoded by the GCLC gene.Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase is the first rate limiting enzyme of glutathione synthesis. The enzyme consists of two subunits, a heavy catalytic subunit and a light regulatory subunit. The gene encoding the catalytic subunit encodes a protein of 367 amino acids with a calculated molecular weight of 72.773 kDa and maps to chromosome 6p12.1. Deficiency of gamma-glutamylcysteine synthetase in human is associated with enzymopathic hemolytic anemia.
Reconstitution and Storage 0.2ml of distilled water will yield a concentration of 500ug/ml. At -20C for one year. After reconstitution, at 4C for one month. It can
also be aliquotted and stored frozen at -20C for a longer time.
Avoid repeated freezing and thawing.
Replacement Item This antibody may replace item sc-115522 from Santa Cruz Biotechnology.
Immunogen A synthetic peptide corresponding to a sequence at the N-terminal ofhuman GCS/GCLC, different from the related rat and mousesequences by one amino acid.
Purification Immunogen affinity purified.
Predicted Homology Based on Immunogen Sequence Human; Mouse; Rat
Datasheets/Manuals Printable datasheet for anti-GCLC (OABB00446) antibody
Specificity Rabbit IgG
Target Reference 1. Gipp, J. J., Chang, C., Mulcahy, R. T.Cloning and nucleotide sequence of a full-length cDNA for
human liver gamma-glutamylcysteine synthetase.Biochem. Biophys. Res. Commun. 185: 29-35,
1992.
2. Sierra-Rivera, E., Summar, M. L., Dasouki, M., Krishnamani, M. R. S., Phillips, J. A., Freeman, M.
L.Assignment of the gene (GLCLC) that encodes the heavy subunit of gamma-glutamylcysteine
synthetase to human chromosome 6.Cytogenet. Cell Genet. 70: 278-279, 1995.
Gene Symbol GCLC
Official Gene Full Name Glutamate--cysteine ligase catalytic subunit
NCBI Gene Id 2729
Protein Name Glutamate--cysteine ligase catalytic subunit
Swissprot Id P48506
Protein Accession # NP_001184044.1; NP_001489.1
Nucleotide Accession # NM_001197115.1; NM_001498.3
Tissue Tool Find tissues and cell lines supported by DNA array analysis to express GCLC.
RNA Seq Find tissues and cell lines supported by RNA-seq analysis to express GCLC.
  1. What is the species homology for "GCLC Antibody (OABB00446)"?

    The tested species reactivity for this item is "". This antibody is predicted to have homology to "Human, Mouse, Rat".

  2. How long will it take to receive "GCLC Antibody (OABB00446)"?

    This item is available "Domestic: within 1 week delivery | International: 1 week".

  3. What buffer format is "GCLC Antibody (OABB00446)" provided in?

    This item is provided in "Lyophilized".
    Additional format options may be available. For more information please contact info@avivasysbio.com.

  4. What are other names for "GCLC Antibody (OABB00446)"?

    This target may also be called "" in publications.

  5. What is the shipping cost for "GCLC Antibody (OABB00446)"?

    The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.

  6. What is the guarantee for "GCLC Antibody (OABB00446)"?

    All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.

  7. Can I get bulk pricing for "GCLC Antibody (OABB00446)"?

    You can get bulk pricing for this item by going here.

  8. What is the molecular weight of the protein?

    The molecular weight reported by Uniprot for this item is "".
    Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics.

  9. What protocols are available for "GCLC Antibody (OABB00446)"?

    We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data tab on the product page.

  10. What are positive controls for "GCLC"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  11. What are negative controls for "GCLC"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  12. What other proteins interact with "GCLC"?

    This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.

  13. What biological processes are associated with "GCLC"?

    This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.

  14. What cellular components are associated with "GCLC"?

    This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.

  15. What protein functions are associated with "GCLC"?

    This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.

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