Size:100 ul
Special Price $229.00 Regular Price $319.00
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ARP54577_P050
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Conjugation Options

ARP54577_P050-FITC Conjugated

ARP54577_P050-HRP Conjugated

ARP54577_P050-Biotin Conjugated

GCLC Antibody - middle region (ARP54577_P050)

Catalog#: ARP54577_P050
Domestic: within 1-2 days delivery International: 1-2 days
More Information
Tested Species ReactivityHuman, Mouse
Predicted Species ReactivityCow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Yeast, Zebrafish
Product FormatLiquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
ClonalityPolyclonal
HostRabbit
ApplicationIHC, WB
Reconstitution and StorageFor short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
Replacement ItemThis antibody may replace item sc-115522 from Santa Cruz Biotechnology.
ImmunogenThe immunogen is a synthetic peptide directed towards the middle region of human GCLC
PurificationAffinity Purified
Predicted Homology Based on Immunogen SequenceCow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Yeast: 100%; Zebrafish: 100%
Complete computational species homology dataAnti-GCLC (ARP54577_P050)
Peptide SequenceSynthetic peptide located within the following region: RISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVA
ConcentrationBatch dependent within range: 100 ul at 0.5 - 1 mg/ml
Blocking PeptideFor anti-GCLC (ARP54577_P050) antibody is Catalog # AAP54577 (Previous Catalog # AAPP44516)
Datasheets/ManualsPrintable datasheet for anti-GCLC (ARP54577_P050) antibody
Publications

Bardag-Gorce, F. et al. Proteasome inhibitor up regulates liver antioxidative enzymes in rat model of alcoholic liver disease. Exp. Mol. Pathol. 90, 123-30 (2011). IHC, WB, Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Yeast, Zebrafish 21036165

Ramani, K., Tomasi, M. L., Yang, H., Ko, K. & Lu, S. C. Mechanism and significance of changes in glutamate-cysteine ligase expression during hepatic fibrogenesis. J. Biol. Chem. 287, 36341-55 (2012). IHC, WB, Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Yeast, Zebrafish 22942279

Gene SymbolGCLC
Official Gene Full NameGlutamate-cysteine ligase, catalytic subunit
Alias SymbolsGCL, GCS, GLCL, GLCLC
NCBI Gene Id2729
Protein NameGlutamate--cysteine ligase catalytic subunit
Description of TargetGlutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase is the first rate limiting enzyme of glutathione synthesis. The enzyme consists of two subunits, a heavy catalytic subunit and a light regulatory subunit. GCLC is the catalytic subunit of 637 amino acids with a calculated molecular weight of 72.773 kDa. Deficiency of gamma-glutamylcysteine synthetase in human is associated with enzymopathic hemolytic anemia.
Swissprot IdP48506
Protein Accession #NP_001489
Nucleotide Accession #NM_001498
Protein Size (# AA)637
Molecular Weight73kDa
Tissue ToolFind tissues and cell lines supported by DNA array analysis to express GCLC.
RNA SeqFind tissues and cell lines supported by RNA-seq analysis to express GCLC.
Protein InteractionsUBC; PPID; GCLM; CCL22; PAXIP1; ELAVL1;
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