GCG Antibody (OAAD00393)

Catalog No: OAAD00393

Size:0.1ml

western blot analysis using GCG mAb against HEK293 (1) and GCG-hIgGFc transfected HEK293 (2) cell lysate.

Product Info

• Predicted Species Reactivity: Human
• Clonality: Monoclonal
• Clone: 2F9
• Isotype: IgG1
• Host: Mouse
• Application: WB
• Reconstitution and Storage: Store at 4C, for long term storage, store at -20C.
• Immunogen: Purified recombinant fragment of human GCG expressed in E. Coli.
• Formulation: Ascitic fluid containing 0.03% sodium azide.
• Application Info: Western Bloting: 1/500 - 1/2000.
  ELISA: Propose dilution 1/10000.
  Not yet tested in other applications.
  Determining optimal working dilutions by titration test.
• Reference: 1. Int J Mol Med. 2008 Jul;22(1):127-32.
  2. Physiol Behav. 2008 Aug 6;94(5):696-9.

Target Info

• Alias Symbols: GLP1, GLP2, GRPP, GLP-1
• NCBI Gene Id: 2641
• Description of Target: The protein encoded by this gene is actually a preproprotein that is cleaved into four distinct mature peptides. One of these, glucagon, is a pancreatic hormone that counteracts the glucose-lowering action of insulin by stimulating glycogenolysis and gluconeogenesis. Glucagon is a ligand for a specific G-protein linked receptor whose signalling pathway controls cell proliferation.
  Two of the other peptides are secreted from gut endocrine cells and promote nutrient absorption through distinct mechanisms.
  Finally, the fourth peptide is similar to glicentin, an active enteroglucagon.Tissue specificity: Glucagon is secreted in the A cells of the islets of Langerhans. GLP-1, GLP-2, oxyntomodulin and glicentin are secreted from enteroendocrine cells throughout the gastrointestinal tract. GLP1 and GLP2 are also secreted in selected neurons in the brain.
• Uniprot ID: P01275
• Molecular Weight: 21kDa