Size:100 ul
Special Price $229.00 Regular Price $249.00
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ARP43559_T100
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Conjugation Options

ARP43559_T100-FITC Conjugated

ARP43559_T100-HRP Conjugated

ARP43559_T100-Biotin Conjugated

GCDH Antibody - C-terminal region (ARP43559_T100)

Catalog#: ARP43559_T100
Domestic: within 1-2 days delivery International: 1-2 days
More Information
Tested Species Reactivity Human
Predicted Species Reactivity Dog, Horse, Human, Mouse, Pig, Rabbit, Rat, Zebrafish
Product Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Clonality Polyclonal
Host Rabbit
Application IHC, WB
Additional Information IHC Information: HepG2 cell lysate. Antibody concentration: 2.5 ug/ml. Gel concentration: 12%.
Reconstitution and Storage For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
Replacement Item This antibody may replace item sc-133610 from Santa Cruz Biotechnology.
Immunogen The immunogen is a synthetic peptide directed towards the C terminal region of human GCDH
Purification Protein A purified
Predicted Homology Based on Immunogen Sequence Dog: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Pig: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 100%
Complete computational species homology data Anti-GCDH (ARP43559_T100)
Peptide Sequence Synthetic peptide located within the following region: IARQARDMLGGNGISDEYHVIRHAMNLEAVNTYEGTHDIHALILGRAITG
Concentration Batch dependent within range: 100 ul at 0.5 - 1 mg/ml
Blocking Peptide For anti-GCDH (ARP43559_T100) antibody is Catalog # AAP43559 (Previous Catalog # AAPP25004)
Datasheets/Manuals Printable datasheet for anti-GCDH (ARP43559_T100) antibody
Target Reference Kimura,K., (2006) Genome Res. 16 (1), 55-65
Publications

Hu, Z. et al. Quantitative liver-specific protein fingerprint in blood: a signature for hepatotoxicity. Theranostics 4, 215-28 (2014). IHC, WB, Dog, Horse, Human, Mouse, Pig, Rabbit, Rat, Zebrafish 24465277

Gene Symbol GCDH
Official Gene Full Name Glutaryl-CoA dehydrogenase
Alias Symbols ACAD5, GCD
NCBI Gene Id 2639
Protein Name Glutaryl-CoA dehydrogenase, mitochondrial
Description of Target GCDH belongs to the acyl-CoA dehydrogenase family. It catalyzes the oxidative decarboxylation of glutaryl-CoA to crotonyl-CoA and CO(2) in the degradative pathway of L-lysine, L-hydroxylysine, and L-tryptophan metabolism. It uses electron transfer flavoprotein as its electron acceptor. The enzyme exists in the mitochondrial matrix as a homotetramer of 45-kD subunits.The protein encoded by this gene belongs to the acyl-CoA dehydrogenase family. It catalyzes the oxidative decarboxylation of glutaryl-CoA to crotonyl-CoA and CO(2) in the degradative pathway of L-lysine, L-hydroxylysine, and L-tryptophan metabolism. It uses electron transfer flavoprotein as its electron acceptor. The enzyme exists in the mitochondrial matrix as a homotetramer of 45-kD subunits. Alternatively spliced transcript variants encoding different isoforms have been identified.
Swissprot Id Q92947
Protein Accession # NP_000150
Nucleotide Accession # NM_000159
Protein Size (# AA) 438
Molecular Weight 48kDa
Tissue Tool Find tissues and cell lines supported by DNA array analysis to express GCDH.
RNA Seq Find tissues and cell lines supported by RNA-seq analysis to express GCDH.
Protein Interactions UBC; FBXO6; ADRB2; RNF32; EXOC6; ECSIT; MAST1; CDC37; PSEN2; PSEN1; NOS3; APOE; A2M; UBD; MYC; GCDH;
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