GBR-12909 2HCl (OOMC00020)

Catalog No: OOMC00020

Product Info

• Product Format: Powder
• Additional Information: CAS: 67469-78-7
  Molecular Formula: C28 H32 F2 N2 O - 2HCl
  Chemical Name: 1-[2-[Bis-(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazine dihydrochloride
  Primary Activity: Dopamine reuptake inhibitor
  COVID-19 Rationale: Sigma receptor agonist (SARS-CoV-2 Nsp6 protein interacts with the Sigma receptor)
• Reconstitution and Storage: Soluble in DMSO (up to 30 mg/ml with warming) or in Water (up to 10 mg/ml with warming). Store at room temperature.
• Purity: > 98%
• Reference: 1) Andersen et al. (1989), The dopamine inhibitor GBR 12909: selectivity and molecular mechanism of action; Eur. J. Pharmacol., 166 493 2) Contreras et al. (1990), GBR-12909 and fluspirilene potently inhibited binding of [3H] (+)3-PPP to sigma receptors in rat brain; Life Sci., 47 PL133 3) Yorgason et al. (2011), Low and high affinity dopamine transporter inhibitors block dopamine uptake within 5 sec of intravenous injection; Neuroscience, 182 125

Target Info

• Alias Symbols: Vanoxerine
• Molecular Weight: 523.50 g/mol