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Catalog No: ARP57630_P050
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ARP57630_P050
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GBL Antibody - middle region (ARP57630_P050)

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Datasheets/ManualsPrintable datasheet for anti-MLST8 (ARP57630_P050) antibody
Product Info
Tested Species ReactivityHuman
Predicted Species ReactivityHuman, Mouse, Rat, Cow, Dog, Goat, Guinea Pig, Horse, Rabbit, Zebrafish
Product FormatLiquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
ClonalityPolyclonal
HostRabbit
ApplicationWB
Reconstitution and StorageFor short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
ImmunogenThe immunogen is a synthetic peptide directed towards the middle region of human GBL
PurificationAffinity Purified
Predicted Homology Based on Immunogen SequenceCow: 100%; Dog: 100%; Goat: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 93%
Peptide SequenceSynthetic peptide located within the following region: CAFSGDSQYIVTASSDNLARLWCVETGEIKREYGGHQKAVVCLAFNDSVL
Concentration0.5 mg/ml
Blocking PeptideFor anti-MLST8 (ARP57630_P050) antibody is Catalog # AAP57630 (Previous Catalog # AAPP42019)
SubunitLST8
Gene SymbolMLST8
Gene Full NameMTOR associated protein, LST8 homolog (S. cerevisiae)
Alias SymbolsGBL, LST8, POP3, WAT1, GbetaL
NCBI Gene Id64223
Protein NameTarget of rapamycin complex subunit LST8
Description of TargetGBL is the subunit of both mTORC1 and mTORC2, which regulate cell growth and survival in response to nutrient and hormonal signals. mTORC1 is activated in response to growth factors or amino-acids. Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at 'Ser-422'. mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657'.
Uniprot IDQ9BVC4
Protein Accession #NP_071767
Nucleotide Accession #NM_022372
Protein Size (# AA)326
Molecular Weight36kDa
Protein InteractionsMTOR; EIF4EBP1; RPTOR; AKT1S1; PRR5L; FKBP8; SUZ12; PRMT1; STAT1; RICTOR; UBC; ATXN1; A2M; DEPTOR; ULK1; RPS6KB1; SQSTM1; Cul4a; Dtl; PRR5; CCT2; KRT85; RHEB;
  1. What is the species homology for "GBL Antibody - middle region (ARP57630_P050)"?

    The tested species reactivity for this item is "Human". This antibody is predicted to have homology to "Human, Mouse, Rat, Cow, Dog, Goat, Guinea Pig, Horse, Rabbit, Zebrafish".

  2. How long will it take to receive "GBL Antibody - middle region (ARP57630_P050)"?

    This item is available "Domestic: within 1-2 days delivery | International: 1-2 days".

  3. What buffer format is "GBL Antibody - middle region (ARP57630_P050)" provided in?

    This item is provided in "Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.".
    Additional format options may be available. For more information please contact info@avivasysbio.com.

  4. What are other names for "GBL Antibody - middle region (ARP57630_P050)"?

    This target may also be called "GBL, LST8, POP3, WAT1, GbetaL" in publications.

  5. What is the shipping cost for "GBL Antibody - middle region (ARP57630_P050)"?

    The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.

  6. What is the guarantee for "GBL Antibody - middle region (ARP57630_P050)"?

    All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.

  7. Can I get bulk pricing for "GBL Antibody - middle region (ARP57630_P050)"?

    You can get bulk pricing for this item by going here.

  8. What is the molecular weight of the protein?

    The molecular weight reported by Uniprot for this item is "36kDa".
    Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics.

  9. What protocols are available for "GBL Antibody - middle region (ARP57630_P050)"?

    We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data" tab on the product page.

  10. What are positive controls for "MLST8"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  11. What are negative controls for "MLST8"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  12. What other proteins interact with "MLST8"?

    This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.

  13. What biological processes are associated with "MLST8"?

    This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.

  14. What cellular components are associated with "MLST8"?

    This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.

  15. What protein functions are associated with "MLST8"?

    This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.

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