GATAD2B Antibody - N-terminal region (ARP39429_P050)

Catalog No: ARP39429_P050

WB Suggested Anti-GATAD2B Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1:312500
Positive Control: HepG2 cell lysate

Product Info

• Tested Species Reactivity: Human
• Predicted Species Reactivity: Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish
• Product Format: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
• Clonality: Polyclonal
• Host: Rabbit
• Application: WB
• Reconstitution and Storage: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
• Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human GATAD2B
• Purification: Affinity Purified
• Predicted Homology Based on Immunogen Sequence: Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 93%
• Peptide Sequence: Synthetic peptide located within the following region: MDRMTEDALRLNLLKRSLDPADERDDVLAKRLKMEGHEAMERLKMLALLK
• Concentration: 0.5 mg/ml
• Blocking Peptide: For anti-GATAD2B (ARP39429_P050) antibody is Catalog # AAP39429 (Previous Catalog # AAPP21444)
• Reference: Beausoleil,S.A., (2004) Proc. Natl. Acad. Sci. U.S.A. 101 (33), 12130-12135

Target Info

• Gene Symbol: GATAD2B
• Gene Full Name: GATA zinc finger domain containing 2B
• Alias Symbols: p68, GANDS, MRD18, P66beta
• NCBI Gene Id: 57459
• Protein Name: Transcriptional repressor p66-beta
• Description of Target: Hp66beta (GATAD2B), previously identified as a component of the human MeCP1 complex, is a second member of a p66 gene family (hp66alpha and hp66beta). Both proteins interact with MBD2 and MBD3 functionally and biochemically. Both factors function in synergy, since knocking-down p66alpha affects the repressive function of p66beta and vice versa. Furthermore, confocal microscopy shows a nuclear colocalization of hp66alpha with hp66beta and MBD2 in a speckled pattern. These two highly related mammalian p66 proteins display overlapping functions and are involved in methylation dependent transcriptional repression.
• Uniprot ID: Q8WXI9
• Protein Accession #: NP_065750
• Nucleotide Accession #: NM_020699
• Protein Size (# AA): 593
• Molecular Weight: 65kDa
• Protein Interactions: USHBP1; CEP70; RPGRIP1; TEX11; MBD3; TRIM27; PRKAB2; GOLGA2; CALCOCO2; TRAF1; SUMO2; UBC; ZBTB1; SUZ12; EED; RNF2; HDAC2; HDAC1; SMAD2; MTA3; NOTCH1; MTA2; MTA1; NDUFA7; NDUFA2; SOX2; PARK7; tat; HIST1H4A; HIST1H3A; HIST2H2BE; HIST2H2AC; RBBP7; RBBP4; Fox